传染病中挥发性有机化合物 (VOC) 的代谢组学研究

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry Pub Date : 2024-10-31 DOI:10.1016/j.trac.2024.118024

Kyrilos Sadaka , Bahram Dalvand , Zoya Faruqui , Saman Aqeel , Marzieh Ghoohestani , Mohammad Goodarzi

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引用次数: 0

摘要

代谢概况是传染性疾病表型和生化活性的直接指标，它包括生物系统中的各种小分子，包括天然产物和表达方式可变的药物成分。代谢组学有助于深入了解新型药物、药物支架和有前景的靶点，有助于提出结合伙伴和探索对抗感染至关重要的天然产物。利用代谢组学可以扩大治疗药物的发现范围，揭示预期和未预期的药物效应。在传染病方面，代谢组学有助于预后和诊断，利用核磁共振或质谱法确定疾病特异性生物标志物。代谢组学还利用先进的通量分析技术发现代谢酶的潜在目标。这篇综合性综述强调了代谢组学在筛选生物标记物、确定治疗感染的药物靶点以及探索免疫代谢组学方面的重要意义。此外，它还重点介绍了挥发性有机化合物 (VOC) 分析的先进分析技术，探讨了化学计量学的应用和不同分析仪器的使用，强调了该领域未来研究的必要性。

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Metabolomics of volatile organic compounds (VOCs) in infectious diseases

The metabolic profile, a direct indicator of phenotype and biochemical activity in infectious diseases, comprises diverse small molecules in biological systems, including natural products and drug components with variable expression. Metabolomics provides insights into novel drugs, drug scaffolds, and promising targets, contributing to suggesting binding partners and exploring natural products crucial in combating infections. Leveraging metabolomics amplifies the discovery of therapeutic agents, revealing anticipated and unforeseen drug effects. In infectious diseases, it contributes to prognostic and diagnostic aspects, employing NMR or mass spectrometry to identify disease-specific biomarkers. Metabolomics also uncovers potential targets among metabolic enzymes, utilizing advanced flux analysis techniques. This comprehensive review emphasizes metabolomics' significance in screening biomarkers, identifying drug targets for infections, and exploring immunometabolomics. Additionally, it focuses on advanced analytical techniques for volatile organic compound (VOC) analysis, addressing the application of chemometrics and the use of different analytical instruments, emphasizing the need for future research in this field.

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来源期刊

Trends in Analytical Chemistry 化学-分析化学

CiteScore

20.00

自引率

4.60%

发文量

257

审稿时长

3.4 months

期刊介绍： TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.