纤维素涂层氧化钒纳米材料的抗癌和急性毒性研究

IF 4 2区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Molecular Structure Pub Date : 2024-11-06 DOI:10.1016/j.molstruc.2024.140633

Zartasha Sarwar , Muhammad Khawar Abbas , Naveed Akhtar Shad , Kanwal Akhtar , Ameena Mobeen , Waseem Abbas , Kh. Abd El-Aziz , Muhammad Rizwan Tabassum , Muhammad Zulqarnain , Hafiz T. Ali , Yasir Javed , Sumara Ashraf

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引用次数: 0

摘要

在本研究工作中，采用了一种简便的水热法来制备原始的和纤维素包覆的氧化钒（V2O5）纳米粒子（NPs）。利用 XRD、SEM、UV-Vis、PL、DLS、拉曼和傅立叶变换红外光谱对合成的纳米结构进行了表征。通过 XRD 分析计算出的裸 V2O5 NPs 的晶粒尺寸为 19 纳米，纤维素功能化后晶粒尺寸减小到 16 纳米。TEM 显微照片显示，V2O5 和纤维素 - V2O5 形成的球形 NPs 大小分别为 21 ± 4.9 nm 和 16.5 ± 4.4 nm。纤维素包裹的氧化钒 NPs 对肝癌细胞株（HuH-7.0）具有抗癌潜力。V2O5 的细胞活力 IC50 值为 102.182 μg/mL，而涂覆氧化钒的 IC50 值为 49.402 μg/mL。使用健康的白化大鼠进行了体内毒性研究。病理学参数表明，纤维素包覆的氧化钒 NPs 具有急性毒性。经纤维素-V2O5 NPs 处理的肝脏的组织病理学显示，肝细胞肿胀，肝窦间隙受压。

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Anticancer and acute toxicity studies of cellulose-coated Vanadium oxide nanomaterials

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Anticancer and acute toxicity studies of cellulose-coated Vanadium oxide nanomaterials

In the present research work, a facile hydrothermal method has been used for the preparation of pristine and cellulose-coated Vanadium oxide (V₂O₅) nanoparticles (NPs). The as-synthesized nanostructures were characterized using XRD, SEM, UV–Vis, PL, DLS, Raman, and FTIR spectroscopy. The crystallite size of the bare V₂O₅ NPs calculated using XRD analysis was ∼19 nm, which was reduced to ∼16 nm after cellulose functionalization. TEM micrographs revealed the formation of spherical shape NPs with sizes 21 ± 4.9 nm and 16.5 ± 4.4 nm for V₂O₅ and cellulose – V₂O₅ respectively. Cellulose-coated Vanadium oxide NPs have shown anticancer potential against the liver cancer cell line (HuH-7.0). Cell viability of V₂O₅ displayed the IC₅₀ value of 102.182 μg/mL, compared to the coated Vanadium oxide, which was 49.402 μg/mL. In vivo toxicity studies were conducted using healthy albino rats. Pathological parameters indicate acute toxicity due to cellulose-coated Vanadium oxide NPs. The histopathology of cellulose-V₂O₅ NPs treated livers indicates the swelling in hepatocytes and compressed sinusoidal spaces.

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来源期刊

Journal of Molecular Structure 化学-物理化学

CiteScore

7.10

自引率

15.80%

发文量

2384

审稿时长

45 days

期刊介绍： The Journal of Molecular Structure is dedicated to the publication of full-length articles and review papers, providing important new structural information on all types of chemical species including: • Stable and unstable molecules in all types of environments (vapour, molecular beam, liquid, solution, liquid crystal, solid state, matrix-isolated, surface-absorbed etc.) • Chemical intermediates • Molecules in excited states • Biological molecules • Polymers. The methods used may include any combination of spectroscopic and non-spectroscopic techniques, for example: • Infrared spectroscopy (mid, far, near) • Raman spectroscopy and non-linear Raman methods (CARS, etc.) • Electronic absorption spectroscopy • Optical rotatory dispersion and circular dichroism • Fluorescence and phosphorescence techniques • Electron spectroscopies (PES, XPS), EXAFS, etc. • Microwave spectroscopy • Electron diffraction • NMR and ESR spectroscopies • Mössbauer spectroscopy • X-ray crystallography • Charge Density Analyses • Computational Studies (supplementing experimental methods) We encourage publications combining theoretical and experimental approaches. The structural insights gained by the studies should be correlated with the properties, activity and/ or reactivity of the molecule under investigation and the relevance of this molecule and its implications should be discussed.