摩洛哥塔扎 Oued Amlil 地区百里香精油的化学成分、生物活性和防腐性能

IF 1.3 4区 化学 Q4 ELECTROCHEMISTRY
N. Chahboun , A. Barrahi , L. Koursaoui , S. Mortada , K. Fahsi , R. Flouchi , K. Karrouchi , M.E.A. Faouzi , M. El Faydy , Hatem A. Abuelizz , Abhinay Thakur , K. Fikri-Benbrahim , A. Zarrouk
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引用次数: 0

摘要

该研究调查了从塔扎 Oued Amlil 地区采集的百里香中提取的精油的抗菌、抗氧化、抗糖尿病、ADMET(吸收-分布-代谢-排泄-毒性)特性和防腐性能。通过气相色谱-质谱(GC-MS)技术对百里香精油的植物化学成分进行分析,确定了非含氧单萜(19.07%)、含氧单萜(77.61%)、非含氧倍半萜(1.44%)和含氧倍半萜(1.88%)。主要成分为香芹酚(59.70 %)、百里酚(16.5 %)和γ-萜品烯(11.11 %)。体外微量稀释抗菌效果测试表明,除了一些革兰氏阴性细菌(假单胞菌、泛氏菌属)表现出抗药性外,百里香油对所有测试细菌都有显著的活性。百里香油还具有抗氧化活性,其 2,2-二苯基-1-苦基肼(DPPH)清除试验的 IC50 值为 5.94±0.22 µg/mL,2,2′-偶氮-双-3-乙基苯并噻唑啉-6-磺酸(ABTS)试验的 IC50 值为 3.03±0.17(µg/mL)。被测油对α-淀粉酶和α-葡萄糖苷酶具有良好的抑制活性,IC50 值分别为 0.92±0.02 mg/mL 和 0.19±0.01 mg/mL。对所发现的百里香精油植物成分的 ADME 研究证实了它们重要的药代动力学和类药物特性。此外,还使用电位极化(PDP)和电化学阻抗光谱(EIS)技术评估了百里香精油对碳钢腐蚀的抑制作用。使用扫描电子显微镜和能量色散 X 射线光谱(SEM-EDS)分析了未抑制和抑制的碳钢试样的表面形态。电化学研究表明,在一摩尔盐酸(1 M HCl)中,百里香油是一种良好的碳钢基底混合缓蚀剂,因为在 303 K 下,400 ppm 的百里香油的缓蚀效率达到 94.4%。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chemical composition, biological activities, and anti-corrosion performance of Moroccan essential oil Thymus vulgaris from the Oued Amlil region, Taza
The study investigated the antibacterial, antioxidant, antidiabetic, ADMET (absorption-distribution-metabolism-excretion-toxicity) properties, and anticorrosion of essential oil extracted from Thymus vulgaris collected in the Oued Amlil region of Taza. The phytochemical profile of the Thymus vulgaris essential oil via gas chromatography-mass spectrometry (GC-MS) technique identified non-oxygenated monoterpenes (19.07 %), oxygenated monoterpenes (77.61 %), non-oxygenated sesquiterpenes (1.44 %), and oxygenated sesquiterpenes (1.88 %). The main constituents were carvacrol (59.70 %), thymol (16.5 %), and γ-terpinene (11.11 %). The in vitro microdilution antibacterial effect test showed significant activity against all tested bacteria, except for some Gram-negative bacteria (Pseudomonas, Pantoae spp.), which showed resistance. Thymus vulgaris oil also showed antioxidant activity, with IC50 values of 5.94±0.22 µg/mL using 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay and 3.03±0.17 (µg/mL) using 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulfonic acid (ABTS) assay. The tested oil revealed good inhibitory activity on α-amylase and α-glucosidase with IC50 values of 0.92±0.02 mg/mL and 0.19±0.01 mg/mL, respectively. The ADME study of the identified phytoconstituents of Thymus vulgaris essential oil confirms their important pharmacokinetic and drug-like properties. Additionally, the inhibitory effect of Thymus vulgaris essential oil on carbon steel corrosion was evaluated using potentiodynamic polarization (PDP) and electrochemical impedance spectroscopy (EIS) techniques. The surface morphology of the uninhibited and inhibited carbon steel coupons was analyzed using scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDS). Electrochemical studies showed that Thymus vulgaris oil acts as a good mixed corrosion inhibitor for carbon steel substrate in one molar of hydrochloric acid (1 M HCl) since an inhibition efficiency of 94.4 % was reached with 400 ppm at 303 K.
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来源期刊
CiteScore
3.00
自引率
20.00%
发文量
714
审稿时长
2.6 months
期刊介绍: International Journal of Electrochemical Science is a peer-reviewed, open access journal that publishes original research articles, short communications as well as review articles in all areas of electrochemistry: Scope - Theoretical and Computational Electrochemistry - Processes on Electrodes - Electroanalytical Chemistry and Sensor Science - Corrosion - Electrochemical Energy Conversion and Storage - Electrochemical Engineering - Coatings - Electrochemical Synthesis - Bioelectrochemistry - Molecular Electrochemistry
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