{"title":"PCSK9蛋白并不一定是重度抑郁症的风险因素。","authors":"Elahe Habibitabar, Shima Khanverdiloo, Mona Doostizadeh, Leila Jahangard, Jamshid Karimi, Gholamreza Shafiee","doi":"10.32598/bcn.2022.4044.1","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Major depressive disorder (MDD) is one of the common psychiatric disorders that is characterized by abnormal neurobiological responses. Proprotein convertase subtilisin/kexin 9 (PCSK9) is important in cholesterol homeostasis.</p><p><strong>Methods: </strong>This study aimed to investigate PCSK9 levels and oxidative stress with MDD disease. The study included 30 patients with MDD and 30 healthy controls. Their blood samples were collected in sterile tubes, and the serum PCSK9 concentration, superoxide dismutase (SOD), and glutathione peroxidase (GPx) activity were determined by ELISA kits. Total antioxidant capacity (TAC), total oxidant status (TOS), malondialdehyde (MDA), and copper concentration were determined manually. There was a significant increase in PCSK9 levels in the patient group (P<0.05).</p><p><strong>Results: </strong>The receiver operating characteristic (ROC) curve with a sensitivity of 57% and specificity of 52% was 0.928 (95% CI, 0.86-0.996) for PCSK9 in the patient group (P<0.001). It was found that MDA (P=0.036) level was higher in the MDD group, but TAC (P=0.445) level, SOD (P=0.148), GPx (P=0.019) activities, and copper concentration were lower in the patient group compared with the control group.</p><p><strong>Conclusion: </strong>The study results confirm the relationship between oxidative stress and MDD and also suggest a link between PCSK9 and MDD disease.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"15 4","pages":"519-530"},"PeriodicalIF":1.0000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565667/pdf/","citationCount":"0","resultStr":"{\"title\":\"The PCSK9 Protein Is Not Necessarily a Risk Factor for Major Depressive Disorder.\",\"authors\":\"Elahe Habibitabar, Shima Khanverdiloo, Mona Doostizadeh, Leila Jahangard, Jamshid Karimi, Gholamreza Shafiee\",\"doi\":\"10.32598/bcn.2022.4044.1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Major depressive disorder (MDD) is one of the common psychiatric disorders that is characterized by abnormal neurobiological responses. Proprotein convertase subtilisin/kexin 9 (PCSK9) is important in cholesterol homeostasis.</p><p><strong>Methods: </strong>This study aimed to investigate PCSK9 levels and oxidative stress with MDD disease. The study included 30 patients with MDD and 30 healthy controls. Their blood samples were collected in sterile tubes, and the serum PCSK9 concentration, superoxide dismutase (SOD), and glutathione peroxidase (GPx) activity were determined by ELISA kits. Total antioxidant capacity (TAC), total oxidant status (TOS), malondialdehyde (MDA), and copper concentration were determined manually. There was a significant increase in PCSK9 levels in the patient group (P<0.05).</p><p><strong>Results: </strong>The receiver operating characteristic (ROC) curve with a sensitivity of 57% and specificity of 52% was 0.928 (95% CI, 0.86-0.996) for PCSK9 in the patient group (P<0.001). It was found that MDA (P=0.036) level was higher in the MDD group, but TAC (P=0.445) level, SOD (P=0.148), GPx (P=0.019) activities, and copper concentration were lower in the patient group compared with the control group.</p><p><strong>Conclusion: </strong>The study results confirm the relationship between oxidative stress and MDD and also suggest a link between PCSK9 and MDD disease.</p>\",\"PeriodicalId\":8701,\"journal\":{\"name\":\"Basic and Clinical Neuroscience\",\"volume\":\"15 4\",\"pages\":\"519-530\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565667/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Basic and Clinical Neuroscience\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.32598/bcn.2022.4044.1\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Basic and Clinical Neuroscience","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32598/bcn.2022.4044.1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
The PCSK9 Protein Is Not Necessarily a Risk Factor for Major Depressive Disorder.
Introduction: Major depressive disorder (MDD) is one of the common psychiatric disorders that is characterized by abnormal neurobiological responses. Proprotein convertase subtilisin/kexin 9 (PCSK9) is important in cholesterol homeostasis.
Methods: This study aimed to investigate PCSK9 levels and oxidative stress with MDD disease. The study included 30 patients with MDD and 30 healthy controls. Their blood samples were collected in sterile tubes, and the serum PCSK9 concentration, superoxide dismutase (SOD), and glutathione peroxidase (GPx) activity were determined by ELISA kits. Total antioxidant capacity (TAC), total oxidant status (TOS), malondialdehyde (MDA), and copper concentration were determined manually. There was a significant increase in PCSK9 levels in the patient group (P<0.05).
Results: The receiver operating characteristic (ROC) curve with a sensitivity of 57% and specificity of 52% was 0.928 (95% CI, 0.86-0.996) for PCSK9 in the patient group (P<0.001). It was found that MDA (P=0.036) level was higher in the MDD group, but TAC (P=0.445) level, SOD (P=0.148), GPx (P=0.019) activities, and copper concentration were lower in the patient group compared with the control group.
Conclusion: The study results confirm the relationship between oxidative stress and MDD and also suggest a link between PCSK9 and MDD disease.
期刊介绍：
BCN is an international multidisciplinary journal that publishes editorials, original full-length research articles, short communications, reviews, methodological papers, commentaries, perspectives and “news and reports” in the broad fields of developmental, molecular, cellular, system, computational, behavioral, cognitive, and clinical neuroscience. No area in the neural related sciences is excluded from consideration, although priority is given to studies that provide applied insights into the functioning of the nervous system. BCN aims to advance our understanding of organization and function of the nervous system in health and disease, thereby improving the diagnosis and treatment of neural-related disorders. Manuscripts submitted to BCN should describe novel results generated by experiments that were guided by clearly defined aims or hypotheses. BCN aims to provide serious ties in interdisciplinary communication, accessibility to a broad readership inside Iran and the region and also in all other international academic sites, effective peer review process, and independence from all possible non-scientific interests. BCN also tries to empower national, regional and international collaborative networks in the field of neuroscience in Iran, Middle East, Central Asia and North Africa and to be the voice of the Iranian and regional neuroscience community in the world of neuroscientists. In this way, the journal encourages submission of editorials, review papers, commentaries, methodological notes and perspectives that address this scope.
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