Jan Reinhard, Stefanie Heidemanns, Markus Rupp, Nike Walter, Derek F Amanatullah, Hellwig Dirk, Volker Alt
{"title":"利用正电子发射断层扫描检测假体周围关节感染的化脓性患者的同步感染灶","authors":"Jan Reinhard, Stefanie Heidemanns, Markus Rupp, Nike Walter, Derek F Amanatullah, Hellwig Dirk, Volker Alt","doi":"10.1016/j.arth.2024.11.015","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Periprosthetic joint infection (PJI) with sepsis is a life-threatening condition and identification of synchronous foci of infection is challenging. Positron emission tomography using <sup>18</sup>F-fluorodeoxyglucose combined with computed tomography (<sup>18</sup>F-FDG-PET/CT) is useful to detect PJI in elective, non-septic patients. We hypothesized that in patients who have PJI and concomitant sepsis requiring intensive care, <sup>18</sup>F-FDG-PET/CT could accurately identify synchronous foci of infection. We addressed the following questions: (1) How often were synchronous foci of infection detected? (2) What were the confirmation rates of these infection foci by other complementary state-of-the-art methods? (3) Did <sup>18</sup>F-FDG-PET/CT findings result in surgical treatment? and (4) What is the risk of synchronous PJI in patients who have PJI and concomitant sepsis who have another indwelling arthroplasty?</p><p><strong>Methods: </strong>We retrospectively analyzed mechanically ventilated septic PJI patients who underwent <sup>18</sup>F-FDG-PET/CT between January 1, 2017, and December 21, 2022. The identified synchronous foci of infection were categorized into musculoskeletal, cardiovascular, pulmonary, or other infections and compared to results from tissue culture, histopathology, magnetic resonance imaging, or transesophageal echocardiography.</p><p><strong>Results: </strong>We identified 17 eligible patients. The <sup>18</sup>F-FDG-PET/CT revealed at least one additional infection focus in 88% (15 of 17) of patients with the following distribution: musculoskeletal (71%, 12 of 17), cardiovascular (18%, 3 of 17), pulmonary (77%, 13 of 17), and other infections (35%, 6 of 17). Synchronous foci of infection identified with <sup>18</sup>F-FDG-PET/CT were confirmed by another state-of-the-art method in 100% (15 of 15) of the patients. Diagnoses with <sup>18</sup>F-FDG-PET/CT led to additional surgery in 65% (11 of 17) of the patients.Of the patients, 59% (10 of 17) had another arthroplasty with a risk of 30% (3 of 10) of synchronous PJI.</p><p><strong>Conclusion: </strong>We highlight the value of <sup>18</sup>F-FDG-PET/CT in patients who have PJI and sepsis, emphasizing its role in the comprehensive evaluation of these patients for subsequent therapeutic decision-making.</p>","PeriodicalId":51077,"journal":{"name":"Journal of Arthroplasty","volume":" ","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Detection of Synchronous Foci of Infection using Positron Emission Tomography in Septic Patients Who Have a Periprosthetic Joint Infection.\",\"authors\":\"Jan Reinhard, Stefanie Heidemanns, Markus Rupp, Nike Walter, Derek F Amanatullah, Hellwig Dirk, Volker Alt\",\"doi\":\"10.1016/j.arth.2024.11.015\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Periprosthetic joint infection (PJI) with sepsis is a life-threatening condition and identification of synchronous foci of infection is challenging. Positron emission tomography using <sup>18</sup>F-fluorodeoxyglucose combined with computed tomography (<sup>18</sup>F-FDG-PET/CT) is useful to detect PJI in elective, non-septic patients. We hypothesized that in patients who have PJI and concomitant sepsis requiring intensive care, <sup>18</sup>F-FDG-PET/CT could accurately identify synchronous foci of infection. We addressed the following questions: (1) How often were synchronous foci of infection detected? (2) What were the confirmation rates of these infection foci by other complementary state-of-the-art methods? (3) Did <sup>18</sup>F-FDG-PET/CT findings result in surgical treatment? and (4) What is the risk of synchronous PJI in patients who have PJI and concomitant sepsis who have another indwelling arthroplasty?</p><p><strong>Methods: </strong>We retrospectively analyzed mechanically ventilated septic PJI patients who underwent <sup>18</sup>F-FDG-PET/CT between January 1, 2017, and December 21, 2022. The identified synchronous foci of infection were categorized into musculoskeletal, cardiovascular, pulmonary, or other infections and compared to results from tissue culture, histopathology, magnetic resonance imaging, or transesophageal echocardiography.</p><p><strong>Results: </strong>We identified 17 eligible patients. The <sup>18</sup>F-FDG-PET/CT revealed at least one additional infection focus in 88% (15 of 17) of patients with the following distribution: musculoskeletal (71%, 12 of 17), cardiovascular (18%, 3 of 17), pulmonary (77%, 13 of 17), and other infections (35%, 6 of 17). Synchronous foci of infection identified with <sup>18</sup>F-FDG-PET/CT were confirmed by another state-of-the-art method in 100% (15 of 15) of the patients. Diagnoses with <sup>18</sup>F-FDG-PET/CT led to additional surgery in 65% (11 of 17) of the patients.Of the patients, 59% (10 of 17) had another arthroplasty with a risk of 30% (3 of 10) of synchronous PJI.</p><p><strong>Conclusion: </strong>We highlight the value of <sup>18</sup>F-FDG-PET/CT in patients who have PJI and sepsis, emphasizing its role in the comprehensive evaluation of these patients for subsequent therapeutic decision-making.</p>\",\"PeriodicalId\":51077,\"journal\":{\"name\":\"Journal of Arthroplasty\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2024-11-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Arthroplasty\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.arth.2024.11.015\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ORTHOPEDICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Arthroplasty","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.arth.2024.11.015","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ORTHOPEDICS","Score":null,"Total":0}
Detection of Synchronous Foci of Infection using Positron Emission Tomography in Septic Patients Who Have a Periprosthetic Joint Infection.
Introduction: Periprosthetic joint infection (PJI) with sepsis is a life-threatening condition and identification of synchronous foci of infection is challenging. Positron emission tomography using 18F-fluorodeoxyglucose combined with computed tomography (18F-FDG-PET/CT) is useful to detect PJI in elective, non-septic patients. We hypothesized that in patients who have PJI and concomitant sepsis requiring intensive care, 18F-FDG-PET/CT could accurately identify synchronous foci of infection. We addressed the following questions: (1) How often were synchronous foci of infection detected? (2) What were the confirmation rates of these infection foci by other complementary state-of-the-art methods? (3) Did 18F-FDG-PET/CT findings result in surgical treatment? and (4) What is the risk of synchronous PJI in patients who have PJI and concomitant sepsis who have another indwelling arthroplasty?
Methods: We retrospectively analyzed mechanically ventilated septic PJI patients who underwent 18F-FDG-PET/CT between January 1, 2017, and December 21, 2022. The identified synchronous foci of infection were categorized into musculoskeletal, cardiovascular, pulmonary, or other infections and compared to results from tissue culture, histopathology, magnetic resonance imaging, or transesophageal echocardiography.
Results: We identified 17 eligible patients. The 18F-FDG-PET/CT revealed at least one additional infection focus in 88% (15 of 17) of patients with the following distribution: musculoskeletal (71%, 12 of 17), cardiovascular (18%, 3 of 17), pulmonary (77%, 13 of 17), and other infections (35%, 6 of 17). Synchronous foci of infection identified with 18F-FDG-PET/CT were confirmed by another state-of-the-art method in 100% (15 of 15) of the patients. Diagnoses with 18F-FDG-PET/CT led to additional surgery in 65% (11 of 17) of the patients.Of the patients, 59% (10 of 17) had another arthroplasty with a risk of 30% (3 of 10) of synchronous PJI.
Conclusion: We highlight the value of 18F-FDG-PET/CT in patients who have PJI and sepsis, emphasizing its role in the comprehensive evaluation of these patients for subsequent therapeutic decision-making.
期刊介绍：
The Journal of Arthroplasty brings together the clinical and scientific foundations for joint replacement. This peer-reviewed journal publishes original research and manuscripts of the highest quality from all areas relating to joint replacement or the treatment of its complications, including those dealing with clinical series and experience, prosthetic design, biomechanics, biomaterials, metallurgy, biologic response to arthroplasty materials in vivo and in vitro.
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