肠道微生物群与骨髓增生异常综合征：知识现状与未来展望。

IF 5 3区医学 Q1 HEMATOLOGY

Seminars in hematology Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI:10.1053/j.seminhematol.2024.10.006

Marin Simunic, Kathy McGraw, Steven Z Pavletic, Armin Rashidi

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引用次数: 0

摘要

肠道微生物组与健康和许多疾病过程都有机理上的联系。癌症也不例外。在实体瘤和血液系统恶性肿瘤中，越来越多的证据支持肠道微生物组参与肿瘤发生、疾病进展、治疗反应和治疗毒性。与微生物组对免疫系统的调节作用和免疫系统对癌症的强大作用相一致，最有说服力的证据是在癌症免疫疗法中获得的。在此，我们回顾了骨髓增生异常综合征中微生物组效应的知识现状，找出了相关研究中的差距和挑战，并为未来的工作提供了启示。

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Intestinal microbiome and myelodysplastic syndromes: Current state of knowledge and perspectives for future.

The intestinal microbiome has been mechanistically linked with health and many disease processes. Cancer is no exception. Both in solid tumors and hematologic malignancies, there is increasing evidence supporting the involvement of the intestinal microbiome in tumor development, disease progression, response to treatment, and treatment toxicity. Consistent with microbiome mediation of the immune system and the potent effect of the immune system on cancer, the most compelling evidence has been obtained in the setting of cancer immunotherapy. Here, we review the current state of knowledge about microbiome effects in myelodysplastic syndromes, identify gaps and challenges in related research, and provide insights for future work.

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来源期刊

Seminars in hematology 医学-血液学

CiteScore

6.20

自引率

2.80%

发文量

审稿时长

35 days

期刊介绍： Seminars in Hematology aims to present subjects of current importance in clinical hematology, including related areas of oncology, hematopathology, and blood banking. The journal''s unique issue structure allows for a multi-faceted overview of a single topic via a curated selection of review articles, while also offering a variety of articles that present dynamic and front-line material immediately influencing the field. Seminars in Hematology is devoted to making the important and current work accessible, comprehensible, and valuable to the practicing physician, young investigator, clinical practitioners, and internists/paediatricians with strong interests in blood diseases. Seminars in Hematology publishes original research, reviews, short communications and mini- reviews.