隐藏的盟友:细胞外囊泡如何驱动人类真菌病原体的生物膜形成、应激适应和宿主-免疫相互作用。

IF 5.1 1区 生物学 Q1 MICROBIOLOGY
mBio Pub Date : 2024-11-18 DOI:10.1128/mbio.03045-23
Philipp Brandt, Rima Singha, Iuliana V Ene
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引用次数: 0

摘要

致病真菌对人类健康构成了重大威胁,尤其是鉴于侵袭性真菌感染发病率的上升和耐药菌株的出现。这就需要开发疫苗和改进抗真菌策略。最近的研究重点是真菌胞外囊泡(EVs)在细胞间通信和宿主-病原体相互作用中的作用。EVs是一种纳米级的脂质膜结合颗粒,可促进蛋白质、脂质和核酸的转移。在此,我们回顾了不同人类真菌病原体产生的EVs的多方面功能,强调了它们在真菌细胞对不同环境线索的反应及其与宿主免疫细胞的相互作用中的重要性。我们总结了有关 EVs 的研究现状,以及利用这些知识如何在疫苗开发和抗真菌治疗中找到创新方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hidden allies: how extracellular vesicles drive biofilm formation, stress adaptation, and host-immune interactions in human fungal pathogens.

Pathogenic fungi pose a significant threat to human health, especially given the rising incidence of invasive fungal infections and the emergence of drug-resistant strains. This requires the development of vaccines and the advancement of antifungal strategies. Recent studies have focused on the roles of fungal extracellular vesicles (EVs) in intercellular communication and host-pathogen interactions. EVs are nanosized, lipid membrane-bound particles that facilitate the transfer of proteins, lipids, and nucleic acids. Here, we review the multifaceted functions of EVs produced by different human fungal pathogens, highlighting their importance in the response of fungal cells to different environmental cues and their interactions with host immune cells. We summarize the current state of research on EVs and how leveraging this knowledge can lead to innovative approaches in vaccine development and antifungal treatment.

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来源期刊
mBio
mBio MICROBIOLOGY-
CiteScore
10.50
自引率
3.10%
发文量
762
审稿时长
1 months
期刊介绍: mBio® is ASM''s first broad-scope, online-only, open access journal. mBio offers streamlined review and publication of the best research in microbiology and allied fields.
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