水凝胶和兔子角膜中飞秒激光诱导折射率变化（LIRIC）的多光子缩放。

IF 2.9 2区医学 Q2 BIOCHEMICAL RESEARCH METHODS

Biomedical optics express Pub Date : 2024-10-08 eCollection Date: 2024-11-01 DOI:10.1364/BOE.537705

Kaitlin T Wozniak, Zachary A Manning, Ruiting Huang, Steven Cox, Sam C Butler, Sebastian Ferlo, Len Zheleznyak, Lisen Xu, Jonathan D Ellis, Krystel R Huxlin, Wayne H Knox

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引用次数: 0

摘要

为了找到在活体眼球中进行激光诱导屈光度变化（LIRIC）的最佳条件，并确保其安全性和有效性，我们研究了在水凝胶和切除角膜组织中进行该过程的多光子激发缩放。我们研究了三种不同的波长模式：高重复率（HRR）和低重复率（LRR）405 nm 系统，以及 800 nm 和 1035 nm 系统。在所有系统中，LRR 405 nm-LIRIC 能够以最低的平均激光功率产生最大的相移。本文讨论了每种模式的相对优点和缺点，它们关系到未来基于 LIRIC 的人类屈光不正矫正工作。

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Multiphoton scaling of femtosecond laser-induced refractive index change (LIRIC) in hydrogels and rabbit cornea.

To find optimal conditions for performing laser induced refractive index change (LIRIC) in living eyes with both safety and efficacy, we investigated multiphoton excitation scaling of this procedure in hydrogel and excised corneal tissue. Three distinct wavelength modalities were examined: high-repetition-rate (HRR) and low-repetition-rate (LRR) 405 nm systems, as well as 800 nm and 1035 nm systems, whose LIRIC-inducing properties are described for the first time. Of all the systems, LRR 405 nm-LIRIC was able to produce the highest phase shifts at the lowest average laser powers. Relative merits and drawbacks to each modality are discussed as they relate to future efforts towards LIRIC-based refractive error correction in humans.

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来源期刊

Biomedical optics express BIOCHEMICAL RESEARCH METHODS-OPTICS

CiteScore

6.80

自引率

11.80%

发文量

633

审稿时长

1 months

期刊介绍： The journal''s scope encompasses fundamental research, technology development, biomedical studies and clinical applications. BOEx focuses on the leading edge topics in the field, including: Tissue optics and spectroscopy Novel microscopies Optical coherence tomography Diffuse and fluorescence tomography Photoacoustic and multimodal imaging Molecular imaging and therapies Nanophotonic biosensing Optical biophysics/photobiology Microfluidic optical devices Vision research.