Baz Delshad, Mirjam Ljunggren, Xing Wu Zhou, J Theorell-Haglöw, Christer Janson, Ding Zou, Jan Hedner, Ludger Grote, Anders Blomberg, Karl Franklin, Carlin Sahlin, Andrei Malinovschi, Eva Lindberg
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The current analysis included data from three centres (Gothenburg, Umeå and Uppsala) on whole-night respiratory polygraphy as a meta-analysis examining the overall effect size of lung function on sleep apnoea severity, expressed as ß-coefficient after stratifying for sex and adjusting for age, waist circumference and smoking status.</p><p><strong>Results: </strong>Data from 9016 participants (54% women, age 58±4 years, body mass index 27±4 kg/m<sup>2</sup> ) with sleep recordings of good quality were included in the final analysis. Forced expiratory volume during 1 s (FEV <sub>1</sub> ) (ß=-0.10 (95% CI -0.16 to -0.03)), forced vital capacity (FVC) (-0.15 (-0.21 to -0.10)) and diffusion capacity for carbon monoxide (DL<sub>CO</sub> ) (-0.08 (-0.10 to -0.05)) were all negatively associated with the oxygen desaturation index (ODI) and also with per cent of registration with nocturnal oxygen saturation <90% FVC (-0.44 (-0.87 to -0.01)), FEV <sub>1</sub> (-0.86 (-1.36 to -0.36)) and DL <sub>CO</sub> (-0.47 (-0.60 to -0.35)). Additionally, a positive association was observed between FEV <sub>1</sub> (0.13 (0.05 to 0.22)) and DL <sub>CO</sub> (0.07 (0.04 to 0.09)) with the mean nocturnal saturation. There was a negative association between DL <sub>CO</sub> and apnoea-hypopnoea index, AHI, (ß=-0.04 (95% CI-0.06 to -0.03)), while no associations were found between FEV <sub>1</sub> or FVC and AHI.</p><p><strong>Conclusion: </strong>In OSA, lower lung function is more distinctly associated with the nocturnal hypoxic burden than AHI. Potential lung function impairment should be investigated in OSA patients with a high ODI relative to AHI.</p>","PeriodicalId":9158,"journal":{"name":"BMJ Open","volume":null,"pages":null},"PeriodicalIF":2.4000,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Obstructive sleep apnoea and lung function, and their association with nocturnal hypoxemia: results from the Swedish CArdioPulmonary bioimage Study (SCAPIS) - a cross-sectional study.\",\"authors\":\"Baz Delshad, Mirjam Ljunggren, Xing Wu Zhou, J Theorell-Haglöw, Christer Janson, Ding Zou, Jan Hedner, Ludger Grote, Anders Blomberg, Karl Franklin, Carlin Sahlin, Andrei Malinovschi, Eva Lindberg\",\"doi\":\"10.1136/bmjopen-2024-086596\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Obstructive sleep apnoea (OSA) and its associations with lung function.</p><p><strong>Background: </strong>OSA is highly prevalent and characterised by abnormal respiration during sleep. This large, population-based study aimed to investigate the associations between OSA and lung function in subjects aged 50-64 years.</p><p><strong>Method: </strong>The population-based Swedish CArdioPulmonary bioimage Study includes information on anthropometry, comorbidities and spirometry. The current analysis included data from three centres (Gothenburg, Umeå and Uppsala) on whole-night respiratory polygraphy as a meta-analysis examining the overall effect size of lung function on sleep apnoea severity, expressed as ß-coefficient after stratifying for sex and adjusting for age, waist circumference and smoking status.</p><p><strong>Results: </strong>Data from 9016 participants (54% women, age 58±4 years, body mass index 27±4 kg/m<sup>2</sup> ) with sleep recordings of good quality were included in the final analysis. Forced expiratory volume during 1 s (FEV <sub>1</sub> ) (ß=-0.10 (95% CI -0.16 to -0.03)), forced vital capacity (FVC) (-0.15 (-0.21 to -0.10)) and diffusion capacity for carbon monoxide (DL<sub>CO</sub> ) (-0.08 (-0.10 to -0.05)) were all negatively associated with the oxygen desaturation index (ODI) and also with per cent of registration with nocturnal oxygen saturation <90% FVC (-0.44 (-0.87 to -0.01)), FEV <sub>1</sub> (-0.86 (-1.36 to -0.36)) and DL <sub>CO</sub> (-0.47 (-0.60 to -0.35)). Additionally, a positive association was observed between FEV <sub>1</sub> (0.13 (0.05 to 0.22)) and DL <sub>CO</sub> (0.07 (0.04 to 0.09)) with the mean nocturnal saturation. 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引用次数: 0
摘要
阻塞性睡眠呼吸暂停（OSA）及其与肺功能的关系：背景：OSA的发病率很高，其特点是睡眠时呼吸异常。这项基于人群的大型研究旨在调查 50-64 岁受试者中 OSA 与肺功能之间的关联：方法：瑞典CArdio-Pulmonary bioimage人口研究包括人体测量、合并症和肺活量测定等信息。目前的分析包括来自三个中心（哥德堡、于默奥和乌普萨拉）的整夜呼吸测谎数据，作为一项荟萃分析，研究肺功能对睡眠呼吸暂停严重程度的总体影响大小，在对性别进行分层并对年龄、腰围和吸烟状况进行调整后，以 ß 系数表示：最终分析纳入了 9016 名参与者（54% 为女性，年龄为 58±4 岁，体重指数为 27±4 kg/m2）的数据，这些参与者的睡眠记录质量良好。1 秒内用力呼气容积 (FEV 1 ) (ß=-0.10 (95% CI -0.16 to -0.03))、用力呼吸容量 (FVC) (-0.15 (-0.21 to -0.10))和一氧化碳弥散容量 (DLCO ) (-0.08 (-0.10 to -0.05))均与睡眠质量呈负相关。05））均与血氧饱和度指数（ODI）呈负相关，也与夜间血氧饱和度为 1 的登记百分比（-0.86（-1.36 至-0.36））和 DL CO（-0.47（-0.60 至-0.35））呈负相关。此外，还观察到 FEV 1 (0.13 (0.05 to 0.22)) 和 DL CO (0.07 (0.04 to 0.09))与平均夜间饱和度之间存在正相关。DL CO与呼吸暂停-低通气指数（AHI）呈负相关（ß=-0.04 (95% CI-0.06 to -0.03)），而FEV 1或FVC与AHI之间没有关联：结论：与 AHI 相比，OSA 患者较低的肺功能与夜间缺氧负荷的关系更为明显。对于 ODI 相对于 AHI 较高的 OSA 患者，应检查其潜在的肺功能损害。
Obstructive sleep apnoea and lung function, and their association with nocturnal hypoxemia: results from the Swedish CArdioPulmonary bioimage Study (SCAPIS) - a cross-sectional study.
Obstructive sleep apnoea (OSA) and its associations with lung function.
Background: OSA is highly prevalent and characterised by abnormal respiration during sleep. This large, population-based study aimed to investigate the associations between OSA and lung function in subjects aged 50-64 years.
Method: The population-based Swedish CArdioPulmonary bioimage Study includes information on anthropometry, comorbidities and spirometry. The current analysis included data from three centres (Gothenburg, Umeå and Uppsala) on whole-night respiratory polygraphy as a meta-analysis examining the overall effect size of lung function on sleep apnoea severity, expressed as ß-coefficient after stratifying for sex and adjusting for age, waist circumference and smoking status.
Results: Data from 9016 participants (54% women, age 58±4 years, body mass index 27±4 kg/m2 ) with sleep recordings of good quality were included in the final analysis. Forced expiratory volume during 1 s (FEV 1 ) (ß=-0.10 (95% CI -0.16 to -0.03)), forced vital capacity (FVC) (-0.15 (-0.21 to -0.10)) and diffusion capacity for carbon monoxide (DLCO ) (-0.08 (-0.10 to -0.05)) were all negatively associated with the oxygen desaturation index (ODI) and also with per cent of registration with nocturnal oxygen saturation <90% FVC (-0.44 (-0.87 to -0.01)), FEV 1 (-0.86 (-1.36 to -0.36)) and DL CO (-0.47 (-0.60 to -0.35)). Additionally, a positive association was observed between FEV 1 (0.13 (0.05 to 0.22)) and DL CO (0.07 (0.04 to 0.09)) with the mean nocturnal saturation. There was a negative association between DL CO and apnoea-hypopnoea index, AHI, (ß=-0.04 (95% CI-0.06 to -0.03)), while no associations were found between FEV 1 or FVC and AHI.
Conclusion: In OSA, lower lung function is more distinctly associated with the nocturnal hypoxic burden than AHI. Potential lung function impairment should be investigated in OSA patients with a high ODI relative to AHI.
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