Burcu Tepekule, Lisa Jörimann, Corinne D Schenkel, Lennart Opitz, Jasmin Tschumi, Rebekka Wolfensberger, Kathrin Neumann, Katharina Kusejko, Marius Zeeb, Lucas Boeck, Marisa Kälin, Julia Notter, Hansjakob Furrer, Matthias Hoffmann, Hans H Hirsch, Alexandra Calmy, Matthias Cavassini, Niklaus D Labhardt, Enos Bernasconi, Gabriela Oesch, Karin J Metzner, Dominique L Braun, Huldrych F Günthard, Roger D Kouyos, Fergal Duffy, Johannes Nemeth
{"title":"艾滋病病毒感染者感染结核分枝杆菌的转录谱。","authors":"Burcu Tepekule, Lisa Jörimann, Corinne D Schenkel, Lennart Opitz, Jasmin Tschumi, Rebekka Wolfensberger, Kathrin Neumann, Katharina Kusejko, Marius Zeeb, Lucas Boeck, Marisa Kälin, Julia Notter, Hansjakob Furrer, Matthias Hoffmann, Hans H Hirsch, Alexandra Calmy, Matthias Cavassini, Niklaus D Labhardt, Enos Bernasconi, Gabriela Oesch, Karin J Metzner, Dominique L Braun, Huldrych F Günthard, Roger D Kouyos, Fergal Duffy, Johannes Nemeth","doi":"10.1016/j.isci.2024.111228","DOIUrl":null,"url":null,"abstract":"<p><p>In people with HIV-1 (PWH), <i>Mycobacterium tuberculosis</i> (MTB) infection poses a significant threat. While active tuberculosis (TB) accelerates immunodeficiency, the interaction between MTB and HIV-1 during asymptomatic phases remains unclear. Analysis of peripheral blood mononuclear cells (PBMC) transcriptomic profiles in PWH, with and without controlled viral loads, revealed distinct clustering in MTB-infected individuals. Functional annotation identified alterations in IL-6, TNF, and KRAS pathways. Notably, MTB-related genes displayed an inverse correlation with HIV-1 viremia, at both individual and signature score levels. These findings suggest that MTB infection in PWH induces a shift in immune system activation, inversely related to HIV-1 viral load. These results may explain the observed enhanced antiretroviral control in MTB-infected PWH. This study highlights the complex interplay between MTB and HIV-1, emphasizing the importance of understanding their interaction for managing co-infections in this population.</p>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 11","pages":"111228"},"PeriodicalIF":4.6000,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565417/pdf/","citationCount":"0","resultStr":"{\"title\":\"Transcriptional profile of <i>Mycobacterium tuberculosis</i> infection in people living with HIV.\",\"authors\":\"Burcu Tepekule, Lisa Jörimann, Corinne D Schenkel, Lennart Opitz, Jasmin Tschumi, Rebekka Wolfensberger, Kathrin Neumann, Katharina Kusejko, Marius Zeeb, Lucas Boeck, Marisa Kälin, Julia Notter, Hansjakob Furrer, Matthias Hoffmann, Hans H Hirsch, Alexandra Calmy, Matthias Cavassini, Niklaus D Labhardt, Enos Bernasconi, Gabriela Oesch, Karin J Metzner, Dominique L Braun, Huldrych F Günthard, Roger D Kouyos, Fergal Duffy, Johannes Nemeth\",\"doi\":\"10.1016/j.isci.2024.111228\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In people with HIV-1 (PWH), <i>Mycobacterium tuberculosis</i> (MTB) infection poses a significant threat. While active tuberculosis (TB) accelerates immunodeficiency, the interaction between MTB and HIV-1 during asymptomatic phases remains unclear. Analysis of peripheral blood mononuclear cells (PBMC) transcriptomic profiles in PWH, with and without controlled viral loads, revealed distinct clustering in MTB-infected individuals. Functional annotation identified alterations in IL-6, TNF, and KRAS pathways. Notably, MTB-related genes displayed an inverse correlation with HIV-1 viremia, at both individual and signature score levels. These findings suggest that MTB infection in PWH induces a shift in immune system activation, inversely related to HIV-1 viral load. These results may explain the observed enhanced antiretroviral control in MTB-infected PWH. This study highlights the complex interplay between MTB and HIV-1, emphasizing the importance of understanding their interaction for managing co-infections in this population.</p>\",\"PeriodicalId\":342,\"journal\":{\"name\":\"iScience\",\"volume\":\"27 11\",\"pages\":\"111228\"},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-10-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565417/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"iScience\",\"FirstCategoryId\":\"103\",\"ListUrlMain\":\"https://doi.org/10.1016/j.isci.2024.111228\",\"RegionNum\":2,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/11/15 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"iScience","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1016/j.isci.2024.111228","RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/15 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
Transcriptional profile of Mycobacterium tuberculosis infection in people living with HIV.
In people with HIV-1 (PWH), Mycobacterium tuberculosis (MTB) infection poses a significant threat. While active tuberculosis (TB) accelerates immunodeficiency, the interaction between MTB and HIV-1 during asymptomatic phases remains unclear. Analysis of peripheral blood mononuclear cells (PBMC) transcriptomic profiles in PWH, with and without controlled viral loads, revealed distinct clustering in MTB-infected individuals. Functional annotation identified alterations in IL-6, TNF, and KRAS pathways. Notably, MTB-related genes displayed an inverse correlation with HIV-1 viremia, at both individual and signature score levels. These findings suggest that MTB infection in PWH induces a shift in immune system activation, inversely related to HIV-1 viral load. These results may explain the observed enhanced antiretroviral control in MTB-infected PWH. This study highlights the complex interplay between MTB and HIV-1, emphasizing the importance of understanding their interaction for managing co-infections in this population.
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Science has many big remaining questions. To address them, we will need to work collaboratively and across disciplines. The goal of iScience is to help fuel that type of interdisciplinary thinking. iScience is a new open-access journal from Cell Press that provides a platform for original research in the life, physical, and earth sciences. The primary criterion for publication in iScience is a significant contribution to a relevant field combined with robust results and underlying methodology. The advances appearing in iScience include both fundamental and applied investigations across this interdisciplinary range of topic areas. To support transparency in scientific investigation, we are happy to consider replication studies and papers that describe negative results.
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