药物纳米晶体：表面工程及其在靶向给药中的应用。

IF 4.6 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2024-11-15 DOI:10.1016/j.isci.2024.111185

Phattalapol Lhaglham , Luksika Jiramonai , Yaru Jia , Baoying Huang , Yuanyu Huang , Xueyun Gao , Jinchao Zhang , Xing-Jie Liang , Mengliang Zhu

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引用次数: 0

摘要

药物纳米晶体在药物开发中备受关注，因为它们能提高溶解速度和水溶性，有效克服药物疏水性问题，从而提高药物的生物利用度和治疗效果。制备技术的最新进展促进了对药物表面特性的研究，从而产生了有价值的表面工程策略。表面修饰可以稳定药物纳米晶体，使其适用于多功能给药平台。功能化配体进一步提高了靶向给药的潜力，使精准医疗成为可能。本综述重点介绍药物纳米晶体的表面工程，讨论各种制备方法、表面配体设计策略及其在靶向给药尤其是癌症治疗中的应用。最后，还讨论了促进药物纳米晶体发展的挑战和未来方向。药物纳米晶体的表面工程有望为治疗复杂和慢性疾病带来新的机遇，同时拓宽给药系统的应用领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Drug nanocrystals: Surface engineering and its applications in targeted delivery

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Drug nanocrystals: Surface engineering and its applications in targeted delivery

Drug nanocrystals have received significant attention in drug development due to their enhanced dissolution rate and improved water solubility, making them effective in overcoming issues related to drug hydrophobicity, thereby improving drug bioavailability and treatment effectiveness. Recent advances in preparation techniques have facilitated research on drug surface properties, leading to valuable surface engineering strategies. Surface modification can stabilize drug nanocrystals, making them suitable for versatile drug delivery platforms. Functionalized ligands further enhance the potential for targeted delivery, enabling precision medicine. This review focuses on the surface engineering of drug nanocrystals, discussing various preparation methods, surface ligand design strategies, and their applications in targeted drug delivery, especially for cancer treatments. Finally, challenges and future directions are also discussed to promote the development of drug nanocrystals. The surface engineering of drug nanocrystals promises new opportunities for treating complex and chronic diseases while broadening the application of drug delivery systems.

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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