The efficacy and safety of vitamin D supplementation in women with polycystic ovarian syndrome undergoing ovulation induction using letrozole.

Objective: Aim: To examine the role of vitamin D supplementation in PCOS women who failed to ovulation induction by letrozole in previous trials.

Patients and methods: Materials and Methods: The study included 30 women diagnosed with PCOS and were complaining from primary infertility. Those women had previously been treated for 3 months with letrozole to induce ovulation, but there was failure of response to treatment. Those 30 women were selected from a pool of women who were evaluated for serum vitamin D and were proved to have vitamin D def i ciency (<20 ng/ml).

Results: Results: Daily monitoring of ovulation by transvaginal ultrasound was done staring from day 7 till day 25 of the cycle. The main outcomes were the number and the size of follicles. In addition, they were followed up for evidence of pregnancy using biochemical serum and urine examination.

Conclusion: Conclusions: When women with polycystic ovarian syndrome are treated with letrozole, vitamin D supplementation enhances both the result of ovulation induction and pregnancy.