钯催化 N-苯酰基吡咯-2-甲腈和芳基硼酸合成吡咯并[1,2-α]吡嗪类化合物

IF 2 3区化学 Q2 CHEMISTRY, ORGANIC

Journal of Heterocyclic Chemistry Pub Date : 2024-09-27 DOI:10.1002/jhet.4898

Hyejun Park, Seunghwan Shim, Hayoung Jeon, Hwayoung Lee, Kiho Lee, Kyeong Lee, Jae Kyun Lee, Hitesh B. Jalani, Yongseok Choi

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引用次数: 0

摘要

在此，我们开发了钯-三氟乙酸盐催化的吡咯-2-甲腈和芳基硼酸的羧基钯化反应，在彻底优化的反应条件下生成了功能多样的吡咯并[1,2-α]吡嗪类化合物。该反应进行顺利，并允许以多样性为导向合成吡咯并[1,2-α]吡嗪，与吡咯-2-碳腈和芳基硼酸相比，该反应具有广泛的底物范围。

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Palladium-Catalyzed Synthesis of Pyrrolo[1,2-α]Pyrazines From N-Phenacyl Pyrrole-2-Carbonitriles and Aryl Boronic Acids

Herein, we have developed palladium-trifluoroacetate-catalyzed carbo-palladation reaction of pyrrole-2-carbonitriles and aryl boronic acids leading to functionally diverse pyrrolo[1,2-α]pyrazines under thoroughly optimized reaction conditions. The reaction proceeded smoothly and allowed the diversity-oriented synthesis of pyrrolo[1,2-α]pyrazines with broad substrate scope with respect to pyrrole-2-carbonitriles and aryl boronic acids.

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来源期刊

Journal of Heterocyclic Chemistry 化学-有机化学

CiteScore

5.20

自引率

4.20%

发文量

177

审稿时长

3.9 months

期刊介绍： The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.