热衷小事,保持活力:我在病毒学和免疫学领域的职业生涯。

IF 8.7 1区 农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Linda J Saif
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引用次数: 0

摘要

对科学和动物的热爱、坚持不懈的努力以及偶然的机遇推动了我在兽医病毒学和免疫学领域的职业生涯。我的研究重点是新生家畜和人类的致命肠道和呼吸道病毒感染,旨在了解其流行情况、发病机制、种间传播和免疫,并开发疫苗。对动物冠状病毒(CoVs)的研究,包括其广泛的种间传播,为了解新出现的人畜共患致命性人类呼吸道冠状病毒[严重急性呼吸系统综合征、中东呼吸系统综合征、严重急性呼吸系统综合征冠状病毒-2(SARS-CoV-2)]和 SARS-CoV-2 对动物的反向人畜共患病奠定了基础。我早期研究的一个亮点是发现了肠道-乳腺-IgA 轴,记录了共同的粘膜免疫系统。后者对于设计母体疫苗以获得新生儿的被动免疫仍然至关重要。我们发现并创新性地在无菌动物中繁殖快速的人类和动物轮状病毒和卡里西病毒及其感染性,为正在进行的病毒学和免疫学研究以及疫苗提供了细胞适应和动物疾病模型。然而,除了研究发现,我的永久遗产仍然是那些丰富了我的科学和生活的杰出导师们。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Passion for Small Things and Staying Primed: My Career in Virology and Immunology.

A love of science and animals, perseverance, and happenstance propelled my career in veterinary virology and immunology. I have focused on deadly enteric and respiratory viral infections in neonatal livestock and humans with an aim to understand their prevalence, pathogenesis, interspecies transmission, and immunity and develop vaccines. Research on animal coronaviruses (CoVs), including their broad interspecies transmission, provided a foundation to understand emerging zoonotic fatal human respiratory CoVs [severe acute respiratory syndrome, Middle East respiratory syndrome, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)] and reverse zoonosis of SARS-CoV-2 to animals. A highlight of my early research was the discovery of the gut-mammary gland-sIgA axis, documenting a common mucosal immune system. The latter remains pivotal to designing maternal vaccines for passive immunity in neonates. Our discovery and innovative cell propagation of fastidious human and animal rotaviruses and caliciviruses and their infectivity in germ-free animals has provided cell-adapted and animal disease models for ongoing virologic and immunologic investigations and vaccines. Nevertheless, besides the research discoveries, my lasting legacy remains the outstanding mentees who have enriched my science and my life.

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来源期刊
Annual Review of Animal Biosciences
Annual Review of Animal Biosciences BIOTECHNOLOGY & APPLIED MICROBIOLOGY-ZOOLOGY
CiteScore
21.30
自引率
0.80%
发文量
31
期刊介绍: The Annual Review of Animal Biosciences is primarily dedicated to the fields of biotechnology, genetics, genomics, and breeding, with a special focus on veterinary medicine. This includes veterinary pathobiology, infectious diseases and vaccine development, and conservation and zoo biology. The publication aims to address the needs of scientists studying both wild and domesticated animal species, veterinarians, conservation biologists, and geneticists.
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