Swati Sood, Anil Tiwari, Jyoti Sangwan, Mehak Vohra, Nishant R Sinha, Ratnakar Tripathi, Virender S Sangwan, Rajiv R Mohan
{"title":"表观遗传学在角膜健康和疾病中的作用。","authors":"Swati Sood, Anil Tiwari, Jyoti Sangwan, Mehak Vohra, Nishant R Sinha, Ratnakar Tripathi, Virender S Sangwan, Rajiv R Mohan","doi":"10.1016/j.preteyeres.2024.101318","DOIUrl":null,"url":null,"abstract":"<p><p>Epigenetics plays a vital role in corneal health and diseases. Epigenetic changes regulate the expression of genes by altering the accessibility of chromatin via histone modifications, DNA methylation and miRNAs without altering DNA sequence. Ocular trauma and infections are common causes of corneal damage, vision impairment, and mono/bilateral blindness worldwide. Mounting literature shows that epigenetic modifications can modulate corneal clarity, function, and pathogenesis including inflammation, wound healing, fibrosis, and neovascularization. Additionally, epigenetic modifications can be targeted to reverse corneal pathologies and develop interventional therapies. However, current understanding on how epigenetic modifications lead to corneal abnormalities and diseases is limited. This review provides in-depth knowledge and mechanistic understanding of epigenetics alterations in corneal pathogenesis, and information on potential epigenetic targets for treatment of corneal diseases.</p>","PeriodicalId":21159,"journal":{"name":"Progress in Retinal and Eye Research","volume":" ","pages":"101318"},"PeriodicalIF":18.6000,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Role of epigenetics in corneal health and disease.\",\"authors\":\"Swati Sood, Anil Tiwari, Jyoti Sangwan, Mehak Vohra, Nishant R Sinha, Ratnakar Tripathi, Virender S Sangwan, Rajiv R Mohan\",\"doi\":\"10.1016/j.preteyeres.2024.101318\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Epigenetics plays a vital role in corneal health and diseases. Epigenetic changes regulate the expression of genes by altering the accessibility of chromatin via histone modifications, DNA methylation and miRNAs without altering DNA sequence. Ocular trauma and infections are common causes of corneal damage, vision impairment, and mono/bilateral blindness worldwide. Mounting literature shows that epigenetic modifications can modulate corneal clarity, function, and pathogenesis including inflammation, wound healing, fibrosis, and neovascularization. Additionally, epigenetic modifications can be targeted to reverse corneal pathologies and develop interventional therapies. However, current understanding on how epigenetic modifications lead to corneal abnormalities and diseases is limited. This review provides in-depth knowledge and mechanistic understanding of epigenetics alterations in corneal pathogenesis, and information on potential epigenetic targets for treatment of corneal diseases.</p>\",\"PeriodicalId\":21159,\"journal\":{\"name\":\"Progress in Retinal and Eye Research\",\"volume\":\" \",\"pages\":\"101318\"},\"PeriodicalIF\":18.6000,\"publicationDate\":\"2024-11-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in Retinal and Eye Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.preteyeres.2024.101318\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in Retinal and Eye Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.preteyeres.2024.101318","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
表观遗传学在角膜健康和疾病中发挥着至关重要的作用。表观遗传学变化通过组蛋白修饰、DNA 甲基化和 miRNA 改变染色质的可及性，从而调节基因的表达，而不改变 DNA 序列。眼外伤和感染是全球角膜损伤、视力损伤和单/双侧失明的常见原因。越来越多的文献表明，表观遗传修饰可调节角膜的清晰度、功能和发病机制，包括炎症、伤口愈合、纤维化和新生血管。此外，表观遗传修饰可作为逆转角膜病变和开发介入疗法的靶点。然而，目前对表观遗传修饰如何导致角膜异常和疾病的了解还很有限。本综述将深入介绍表观遗传学改变在角膜发病机制中的作用和机理，并介绍治疗角膜疾病的潜在表观遗传学靶点。
Role of epigenetics in corneal health and disease.
Epigenetics plays a vital role in corneal health and diseases. Epigenetic changes regulate the expression of genes by altering the accessibility of chromatin via histone modifications, DNA methylation and miRNAs without altering DNA sequence. Ocular trauma and infections are common causes of corneal damage, vision impairment, and mono/bilateral blindness worldwide. Mounting literature shows that epigenetic modifications can modulate corneal clarity, function, and pathogenesis including inflammation, wound healing, fibrosis, and neovascularization. Additionally, epigenetic modifications can be targeted to reverse corneal pathologies and develop interventional therapies. However, current understanding on how epigenetic modifications lead to corneal abnormalities and diseases is limited. This review provides in-depth knowledge and mechanistic understanding of epigenetics alterations in corneal pathogenesis, and information on potential epigenetic targets for treatment of corneal diseases.
期刊介绍：
Progress in Retinal and Eye Research is a Reviews-only journal. By invitation, leading experts write on basic and clinical aspects of the eye in a style appealing to molecular biologists, neuroscientists and physiologists, as well as to vision researchers and ophthalmologists.
The journal covers all aspects of eye research, including topics pertaining to the retina and pigment epithelial layer, cornea, tears, lacrimal glands, aqueous humour, iris, ciliary body, trabeculum, lens, vitreous humour and diseases such as dry-eye, inflammation, keratoconus, corneal dystrophy, glaucoma and cataract.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
