欧洲青少年皮肤黑色素瘤的发病率和预后：EUROCARE-6回顾性队列结果。

IF 7.6 1区医学 Q1 ONCOLOGY

European Journal of Cancer Pub Date : 2024-10-24 DOI:10.1016/j.ejca.2024.115079

Alice Indini , Fabio Didoné , Daniela Massi , Susana Puig , Jordi Rubio Casadevall , Damien Bennett , Alexander Katalinic , Arantza Sanvisens , Andrea Ferrari , Paolo Lasalvia , Elena Demuru , Rosalia Ragusa , Alexandra Mayer-da-Silva , Marcel Blum , Mohsen Mousavi , Claudia Kuehni , Ana Mihor , Mario Mandalà , Annalisa Trama , the EUROCARE-6 Working Group

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引用次数: 0

摘要

背景：皮肤黑色素瘤（CM）在青少年和年轻成人（AYA，确诊癌症时年龄为 15-39 岁）中非常罕见，有关青少年和年轻成人 CM 的研究也很少。我们的目的是更新欧洲青少年皮肤黑色素瘤的发病率和存活率，并与其他年龄组和不同时期的发病率和存活率进行比较：我们使用了EUROCARE-6数据库（108个癌症登记处；29个欧盟国家），计算了2010-2014年随访期间欧洲人口（诊断年份：2006-2013年）每10万人/年的发病率（IR）、5年相对存活率（RS）以及诊断后第一年存活的5年RS（2006-2013年诊断的病例）：与男性相比，女性四肢的CM IR较高，而头颈部和躯干的CM IR较低。青壮年的五年存活率为 94%，老年组为 80%。四肢中风的存活率高于头颈部和躯干中风。与青壮年相比，老年组的中风发病率增加得更多。随着时间的推移，所有年龄段的 CM 存活率均有所上升：男性和女性之间的 IR 差异可能是由于不同的行为和 CM 生物学特性造成的。存活率的提高可归因于医疗保健的改善、早期诊断和局部手术治疗。就青少年肿瘤负担而言，发病趋势令人欣慰。我们的研究结果支持这样一种观点，即随着年龄的增长，CM 的侵袭性更强，性别差异可部分解释不同年龄组之间的生存率差异。

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Incidence and prognosis of cutaneous melanoma in European adolescents and young adults (AYAs): EUROCARE-6 retrospective cohort results

Background

Cutaneous melanoma (CM) is rare in adolescents and young adults (AYA, 15–39 years at cancer diagnosis) and studies on CM in AYAs are scarce. Our aim is to update CM incidence and survival in European AYAs and to compare incidence and survival both with other age groups and over time.

Methods

We used the EUROCARE-6 database (108 cancer registries; 29 EU countries), calculating incidence rates (IR) per 100,000 individuals/year in the European population (years of diagnosis: 2006–2013), 5-year relative survival (RS), and 5-year RS conditional to surviving the first year after diagnosis, for the follow-up period 2010–2014 (cases diagnosed in 2006–2013).

Results

The IR of CM in AYA was greater in females than in males, standing at 7. CM IR was higher in the limbs and lower in the head and neck (H&N) and trunk in females compared to males. Five-year RS was 94 % in AYA and 80 % in older age groups. Survival was higher in limb than in H&N and trunk CM. The incidence of CM increased more in older age groups than in AYA. CM survival rose over time for all ages.

Conclusions

Differences in IR between males and females may be due to different behaviors and CM biology. The increase in survival can be attributed to healthcare improvements, early diagnosis, and locoregional surgical treatments. The incidence trends are reassuring in terms of tumor burden in AYA. Our findings support the idea that CM is more aggressive with increasing age and gender differences partially explain survival differences between age groups.

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来源期刊

European Journal of Cancer 医学-肿瘤学

CiteScore

11.50

自引率

4.80%

发文量

953

审稿时长

23 days

期刊介绍： The European Journal of Cancer (EJC) serves as a comprehensive platform integrating preclinical, digital, translational, and clinical research across the spectrum of cancer. From epidemiology, carcinogenesis, and biology to groundbreaking innovations in cancer treatment and patient care, the journal covers a wide array of topics. We publish original research, reviews, previews, editorial comments, and correspondence, fostering dialogue and advancement in the fight against cancer. Join us in our mission to drive progress and improve outcomes in cancer research and patient care.