TIF1 蛋白的免疫调节作用

4区医学 Q2 Biochemistry, Genetics and Molecular Biology

Advances in experimental medicine and biology Pub Date : 2024-01-01 DOI:10.1007/978-981-97-7288-9_6

Qingchen Zhu, Yichuan Xiao

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引用次数: 0

摘要

免疫细胞的功能受到各种分子网络的微妙调控。转录中介因子 1（TIF1）家族蛋白由 TRIM24、TRIM28 和 TRIM33 组成，它们共享一个高度保守的 RING 结构域，该结构域对于作为 E3 泛素连接酶调控蛋白质泛素化至关重要。TIF1 家族蛋白在不同类型的免疫细胞中表达多样，参与调控染色体修饰、DNA 修复、肿瘤进展和免疫等多种细胞功能。在这篇综述中，我们总结了目前有关 TIF1 家族蛋白在调节免疫细胞发育、抗感染免疫、肿瘤免疫学、炎症和自身免疫性疾病中功能的研究。

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The Immune Modulatory Role of TIF1 Proteins.

The function of immune cells is delicately regulated under a variety of molecular networks. Transcriptional intermediary factor 1 (TIF1) family proteins, consisting of TRIM24, TRIM28 and TRIM33, share a highly conserved RING domain that is essential for the regulation of protein ubiquitination functioning as E3 ubiquitin ligases. TIF1 family proteins are diversely expressed in different types of immune cells, and participate in the regulation of various of cellular functions including chromosome modification, DNA repair, tumor progression, and immunity. In this review, we summarized current studies on TIF1 family proteins' functions in the modulation of immune cell development, anti-infection immunity, cancer immunology, inflammation, and autoimmune diseases.

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来源期刊

Advances in experimental medicine and biology 医学-医学：研究与实验

CiteScore

5.90

自引率

0.00%

发文量

465

审稿时长

2-4 weeks

期刊介绍： Advances in Experimental Medicine and Biology provides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields.