托品的高区域选择性脱氢肼化作用。

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

The Journal of Organic Chemistry Pub Date : 2024-11-15 DOI:10.1021/acs.joc.4c02358

Yan Wang, Muliang Zhang, Shi-Kai Tian

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引用次数: 0

摘要

对托品骨架直接进行 C(sp2)-H 键官能化是一种原子经济的策略，可以获得存在于某些生物活性化合物中的取代托品。在此，我们报告了一种通过 C(sp2)-H 键官能化制备 2-肼基托龙的简便方法。多种托品酮参与了与肼的脱氢肼化反应，以中等至良好的产率和极高的区域选择性制备出结构多样的 2-肼基托品酮。该方法的特点是操作简单，反应条件不含金属，因此可容忍各种官能团。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Highly Regioselective Dehydrogenative Hydrazination of Tropones.

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Highly Regioselective Dehydrogenative Hydrazination of Tropones.

Direct C(sp²)-H bond functionalization of the tropone skeleton constitutes an atom-economical strategy to access substituted tropones that exist in some bioactive compounds. Herein, we report a convenient method for the preparation of 2-hydrazinotropones via C(sp²)-H bond functionalization. A variety of tropones participated in the dehydrogenative hydrazination reaction with hydrazine, delivering structurally diverse 2-hydrazinotropones in moderate to good yields with extremely high regioselectivity. This method is featured by operational simplicity and metal-free reaction conditions, thereby tolerating various functional groups.

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来源期刊

The Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： The Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.