韩国妇女的 miRNA 变异（miR-10a、miR-30c、miR-181a、miR-499b）与原发性卵巢功能不全的遗传关联。

IF 3.9 2区医学 Q2 GERIATRICS & GERONTOLOGY

Maturitas Pub Date : 2024-11-07 DOI:10.1016/j.maturitas.2024.108153

Hui Jeong An , Sung Hwan Cho , Chang Soo Ryu , Eun Ju Ko , Hyeon Woo Park , Young Ran Kim , Eun Hee Ahn , Ji Eun Shin , Seong-Soo Joo , Ji Hyang Kim , Nam Keun Kim

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引用次数: 0

摘要

目的：微RNA（miRNA）在转录后调节动物和植物基因表达方面起着关键作用。本研究调查了韩国女性微RNA多态性与原发性卵巢功能不全发生率之间的关系。我们的假设认为，microRNA 的多态性--特别是 miR-10aA > T、miR-30cA > G、miR-181aT > C 和 miR-499bA > G--可能与原发性卵巢功能不全有关，从而影响患上该病的风险：我们对141名患有原发性卵巢功能不全的韩国女性和281名至少有一次活产且无妊娠失败史的对照组个体进行了病例对照研究：我们的研究结果表明，这四种微RNA多态性位点的不同组合与原发性卵巢功能不全的风险增加有关。组合分析显示，在原发性卵巢功能不全患者中，miR-181a/miR-499b TC/AA 等位基因组合的频率明显降低（P我们的数据表明，miR-10aA > T、miR-30cA > G、miR-181aT > C 和 miR-499bA > G 这些 microRNA 多态性的失调有助于调控与原发性卵巢功能不全相关的靶基因。

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Genetic associations of miRNA variants (miR-10a, miR-30c, miR-181a, miR-499b) with primary ovarian insufficiency in Korean women

Objectives

MicroRNAs (miRNAs) are pivotal in post-transcriptionally modulating gene expression in both animals and plants. This study investigates the relationship between microRNA polymorphisms and the occurrence of primary ovarian insufficiency in Korean women. Our hypothesis posits that polymorphisms in microRNAs—specifically miR-10aA > T, miR-30cA > G, miR-181aT > C, and miR-499bA > G—may be linked to primary ovarian insufficiency, influencing the risk of developing the condition.

Methods

We conducted a case-control study of 141 Korean women with primary ovarian insufficiency and 281 control individuals with at least one live birth and no history of pregnancy loss.

Results

Our findings indicate that various combinations of these four microRNA polymorphic sites are associated with an increased risk of primary ovarian insufficiency. The combination analysis indicated a significant decrease in the frequency of the miR-181a/miR-499b TC/AA allele combination in individuals with primary ovarian insufficiency (P < 0.05). Additionally, one-way analysis of variance of data from patients with primary ovarian insufficiency revealed that, in comparison with miR-181aTT, the miR-181aCC genotype was associated with significantly lower levels of both follicle-stimulating hormone and luteinizing hormone, suggesting potential protective effects.

Conclusions

Our data suggest that dysregulation of the miR-10aA > T, miR-30cA > G, miR-181aT > C, and miR-499bA > G polymorphisms in these microRNAs contributes to the regulation of target genes related to primary ovarian insufficiency.

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来源期刊

Maturitas 医学-妇产科学

CiteScore

9.10

自引率

2.00%

发文量

142

审稿时长

40 days

期刊介绍： Maturitas is an international multidisciplinary peer reviewed scientific journal of midlife health and beyond publishing original research, reviews, consensus statements and guidelines, and mini-reviews. The journal provides a forum for all aspects of postreproductive health in both genders ranging from basic science to health and social care. Topic areas include:• Aging• Alternative and Complementary medicines• Arthritis and Bone Health• Cancer• Cardiovascular Health• Cognitive and Physical Functioning• Epidemiology, health and social care• Gynecology/ Reproductive Endocrinology• Nutrition/ Obesity Diabetes/ Metabolic Syndrome• Menopause, Ovarian Aging• Mental Health• Pharmacology• Sexuality• Quality of Life