在病理生理细胞激活过程中，O-GlcNAcylation 的增加将代谢与转录重编程联系起来。

IF 13 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2024-11-07 DOI:10.1016/j.tcb.2024.10.007

Ninon Very, Bart Staels, Jérôme Eeckhoute

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引用次数: 0

摘要

蛋白质 O-连环β-N-乙酰葡萄糖氨酰化（O-GlcNAcylation）的增加已成为哺乳动物细胞活化的标志，它有助于类似沃伯格的代谢重新布线，从而获得新的功能。最新研究进展表明，O-GlcNAcylation 可促进转录调节因子的活性，从而推动基因表达重编程。这可能会为多种病理情况提供新的治疗机会。

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Increased O-GlcNAcylation connects metabolic to transcriptional reprogramming during pathophysiological cell activation.

Increased protein O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) has emerged as a hallmark of mammalian cell activation, contributing to Warburg-like metabolic rewiring allowing the acquisition of new functionalities. Recent advances indicate that O-GlcNAcylation promotes the activity of transcriptional regulators driving gene expression reprogramming. This may offer new therapeutic opportunities in a broad spectrum of pathological conditions.

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.