慢性支气管炎和支气管哮喘:长期职业辐照对马雅克核电工人发病率和死亡率的影响。

IF 1.4 4区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES
Galina Zhuntova, Tamara V Azizova, Maria V Bannikova
{"title":"慢性支气管炎和支气管哮喘:长期职业辐照对马雅克核电工人发病率和死亡率的影响。","authors":"Galina Zhuntova, Tamara V Azizova, Maria V Bannikova","doi":"10.1088/1361-6498/ad90ee","DOIUrl":null,"url":null,"abstract":"<p><p>The information about the radiation risk of non-cancer respiratory diseases is inconsistent and mainly corresponds to mortality. Previously, an increased risk of chronic bronchitis incidence was demonstrated in the cohort of workers employed at the first Russian nuclear facility Mayak Production Association who had been chronically exposed to gamma rays (externally) and to alpha-active plutonium aerosols (internally). Within this retrospective study, we performed analyses of incidence of and mortality from chronic bronchitis and bronchial asthma using improved estimates of radiation doses provided by the \"Mayak Worker Dosimetry System (MWDS) - 2013\". The cohort included 22,377 individuals hired in 1948-1982, and its follow-up was extended by 10 years (to the end of 2018). The excess relative risk of chronic bronchitis incidence per unit radiation dose (ERR/Gy) and the 95% confidence interval (95% CI) were: with the 0-year lag ERR/Gy=0.07 (95% CI -0.01, 0.17) for gamma exposure and ERR/Gy=0.36 (95% CI 0.13, 0.68) for alpha exposure; with the 10-year lag ERR/Gy=0.15 (95% CI 0.04, 0.30) for gamma exposure and ERR/Gy=0.54 (95% CI 0.19, 1.03) for alpha exposure. The chronic bronchitis mortality risk was significantly associated with internal alpha exposure only for certain worker categories: ERR/Gy=4.08 (95% CI 0.59, 14.3) in males; ERR/Gy=7.10 (95% CI 0.31, 70.44) in former smokers; ERR/Gy=7.94 (95% CI 1.71, 30.2) in workers with the smoking index above 20 pack×years. No association was observed in the chronic bronchitis mortality risk with external gamma exposure. No strong evidence was observed for the impact of gamma and alpha exposure on risk of mortality from chronic bronchitis. The study confirmed the significant positive linear association of the chronic bronchitis incidence risk with gamma and alpha radiation doses from occupational chronic external and internal exposure. However, the estimates of ERR/Gy of alpha particles from internal exposure appeared to be almost 2.4-3 times lower than those based on the MWDS-2008. The observed inconsistency requires further clarification. As for bronchial asthma in Mayak workers, no association was demonstrated in the incidence and mortality risks with occupational gamma and alpha radiation exposure.</p>","PeriodicalId":50068,"journal":{"name":"Journal of Radiological Protection","volume":" ","pages":""},"PeriodicalIF":1.4000,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Chronic bronchitis and bronchial asthma: the impact of chronic occupational radiation exposure on incidence and mortality of Mayak nuclear workers.\",\"authors\":\"Galina Zhuntova, Tamara V Azizova, Maria V Bannikova\",\"doi\":\"10.1088/1361-6498/ad90ee\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The information about the radiation risk of non-cancer respiratory diseases is inconsistent and mainly corresponds to mortality. Previously, an increased risk of chronic bronchitis incidence was demonstrated in the cohort of workers employed at the first Russian nuclear facility Mayak Production Association who had been chronically exposed to gamma rays (externally) and to alpha-active plutonium aerosols (internally). Within this retrospective study, we performed analyses of incidence of and mortality from chronic bronchitis and bronchial asthma using improved estimates of radiation doses provided by the \\\"Mayak Worker Dosimetry System (MWDS) - 2013\\\". The cohort included 22,377 individuals hired in 1948-1982, and its follow-up was extended by 10 years (to the end of 2018). The excess relative risk of chronic bronchitis incidence per unit radiation dose (ERR/Gy) and the 95% confidence interval (95% CI) were: with the 0-year lag ERR/Gy=0.07 (95% CI -0.01, 0.17) for gamma exposure and ERR/Gy=0.36 (95% CI 0.13, 0.68) for alpha exposure; with the 10-year lag ERR/Gy=0.15 (95% CI 0.04, 0.30) for gamma exposure and ERR/Gy=0.54 (95% CI 0.19, 1.03) for alpha exposure. The chronic bronchitis mortality risk was significantly associated with internal alpha exposure only for certain worker categories: ERR/Gy=4.08 (95% CI 0.59, 14.3) in males; ERR/Gy=7.10 (95% CI 0.31, 70.44) in former smokers; ERR/Gy=7.94 (95% CI 1.71, 30.2) in workers with the smoking index above 20 pack×years. No association was observed in the chronic bronchitis mortality risk with external gamma exposure. No strong evidence was observed for the impact of gamma and alpha exposure on risk of mortality from chronic bronchitis. The study confirmed the significant positive linear association of the chronic bronchitis incidence risk with gamma and alpha radiation doses from occupational chronic external and internal exposure. However, the estimates of ERR/Gy of alpha particles from internal exposure appeared to be almost 2.4-3 times lower than those based on the MWDS-2008. The observed inconsistency requires further clarification. As for bronchial asthma in Mayak workers, no association was demonstrated in the incidence and mortality risks with occupational gamma and alpha radiation exposure.</p>\",\"PeriodicalId\":50068,\"journal\":{\"name\":\"Journal of Radiological Protection\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-11-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Radiological Protection\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://doi.org/10.1088/1361-6498/ad90ee\",\"RegionNum\":4,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Radiological Protection","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1088/1361-6498/ad90ee","RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 0

摘要

有关非癌症呼吸道疾病辐射风险的信息并不一致,主要与死亡率有关。此前,俄罗斯第一个核设施马雅克生产协会的工人队列中,长期暴露于伽马射线(外部)和α-活性钚气溶胶(内部)的工人慢性支气管炎发病风险增加。在这项回顾性研究中,我们利用 "玛雅克工人剂量测定系统(MWDS)- 2013 "提供的辐射剂量改进估算值,对慢性支气管炎和支气管哮喘的发病率和死亡率进行了分析。该队列包括 22,377 名 1948-1982 年受雇的人员,其随访时间延长了 10 年(至 2018 年底)。单位辐射剂量慢性支气管炎发病率的超额相对风险(ERR/Gy)和95%置信区间(95% CI)分别为:0年滞后ERR/Gy=0.07(95% CI -0.01, 0.伽马辐射的ERR/Gy=0.07(95% CI -0.01,0.17),α辐射的ERR/Gy=0.36(95% CI 0.13,0.68);滞后10年,伽马辐射的ERR/Gy=0.15(95% CI 0.04,0.30),α辐射的ERR/Gy=0.54(95% CI 0.19,1.03)。只有在某些工人类别中,慢性支气管炎的死亡风险才与内部α暴露显著相关:男性的ERR/Gy=4.08(95% CI 0.59,14.3);曾经吸烟者的ERR/Gy=7.10(95% CI 0.31,70.44);吸烟指数超过20包×年的工人的ERR/Gy=7.94(95% CI 1.71,30.2)。慢性支气管炎的死亡风险与外部伽马射线照射没有关联。在伽马射线和阿尔法射线暴露对慢性支气管炎死亡风险的影响方面,没有观察到有力的证据。研究证实,慢性支气管炎发病风险与职业性长期外部和内部伽马和阿尔法辐射剂量呈明显的正线性关系。然而,内部照射所产生的α粒子的ERR/Gy估计值似乎比基于MWDS-2008的估计值低近2.4-3倍。观察到的不一致需要进一步澄清。至于马雅克工人的支气管哮喘,其发病率和死亡风险与职业伽马和阿尔法辐射照射没有关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chronic bronchitis and bronchial asthma: the impact of chronic occupational radiation exposure on incidence and mortality of Mayak nuclear workers.

The information about the radiation risk of non-cancer respiratory diseases is inconsistent and mainly corresponds to mortality. Previously, an increased risk of chronic bronchitis incidence was demonstrated in the cohort of workers employed at the first Russian nuclear facility Mayak Production Association who had been chronically exposed to gamma rays (externally) and to alpha-active plutonium aerosols (internally). Within this retrospective study, we performed analyses of incidence of and mortality from chronic bronchitis and bronchial asthma using improved estimates of radiation doses provided by the "Mayak Worker Dosimetry System (MWDS) - 2013". The cohort included 22,377 individuals hired in 1948-1982, and its follow-up was extended by 10 years (to the end of 2018). The excess relative risk of chronic bronchitis incidence per unit radiation dose (ERR/Gy) and the 95% confidence interval (95% CI) were: with the 0-year lag ERR/Gy=0.07 (95% CI -0.01, 0.17) for gamma exposure and ERR/Gy=0.36 (95% CI 0.13, 0.68) for alpha exposure; with the 10-year lag ERR/Gy=0.15 (95% CI 0.04, 0.30) for gamma exposure and ERR/Gy=0.54 (95% CI 0.19, 1.03) for alpha exposure. The chronic bronchitis mortality risk was significantly associated with internal alpha exposure only for certain worker categories: ERR/Gy=4.08 (95% CI 0.59, 14.3) in males; ERR/Gy=7.10 (95% CI 0.31, 70.44) in former smokers; ERR/Gy=7.94 (95% CI 1.71, 30.2) in workers with the smoking index above 20 pack×years. No association was observed in the chronic bronchitis mortality risk with external gamma exposure. No strong evidence was observed for the impact of gamma and alpha exposure on risk of mortality from chronic bronchitis. The study confirmed the significant positive linear association of the chronic bronchitis incidence risk with gamma and alpha radiation doses from occupational chronic external and internal exposure. However, the estimates of ERR/Gy of alpha particles from internal exposure appeared to be almost 2.4-3 times lower than those based on the MWDS-2008. The observed inconsistency requires further clarification. As for bronchial asthma in Mayak workers, no association was demonstrated in the incidence and mortality risks with occupational gamma and alpha radiation exposure.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Radiological Protection
Journal of Radiological Protection 环境科学-公共卫生、环境卫生与职业卫生
CiteScore
2.60
自引率
26.70%
发文量
137
审稿时长
18-36 weeks
期刊介绍: Journal of Radiological Protection publishes articles on all aspects of radiological protection, including non-ionising as well as ionising radiations. Fields of interest range from research, development and theory to operational matters, education and training. The very wide spectrum of its topics includes: dosimetry, instrument development, specialized measuring techniques, epidemiology, biological effects (in vivo and in vitro) and risk and environmental impact assessments. The journal encourages publication of data and code as well as results.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信