二苯甲酮-3 对成年斑马鱼肝脏和甲状腺的影响

IF 1.3 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Felismário Medeiros da Silva, Renan Pena Modesto, Mirelly Cândida Cávoli Lira, Eduardo Libanio Reis Santos, Jeffesson de Oliveira-Lima
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引用次数: 0

摘要

1.二苯甲酮-3(BP-3),俗称氧苯酮,是一种有机化合物,具有防晒作用,可保护皮肤免受 UVA 和 UVB 射线的伤害。因此,本研究的目的是利用形态学和生物化学方法研究 BP-3 对肝脏和甲状腺的影响。 2. 将成年雄性斑马鱼随机分为三组,每组重复三次(每组 n = 10):水对照组、溶剂对照组(0.01% 乙醇)和 1 μg/L BP-3 组,采用静态暴露系统,暴露时间为 96 小时。实验结束后,对肝脏和甲状腺进行了组织病理学分析,同时还进行了组织化学分析(糖原)和抗氧化酶超氧化物歧化酶(SOD)和过氧化氢酶(CAT)的生化评估。 暴露于 BP-3 会导致丹瑞欧的肝脏发生显著的组织病理学变化,增加循环障碍、进行性变化、炎症反应和退行性变化的频率。另一方面,甲状腺在暴露于 BP-3 期间没有发生任何形态变化,保持了其典型的滤泡结构。接触 BP-3 96 小时后,SOD 活性明显增加,而 CAT 则没有变化。 4. 所获得的结果表明,接触 BP-3 会导致 D. rerio 的肝脏发生显著的形态生理变化,这不仅凸显了该物质对这些生物健康的负面影响,还表明了该物质的生态毒理学潜力及其对污染环境中水生生物群的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of benzophenone-3 on the liver and thyroid of adult zebrafish.

1. Benzophenone-3 (BP-3), commonly known as oxybenzone, is an organic compound that acts as a sunscreen, protecting the skin from UVA and UVB rays. Thus, the objective of this study was to investigate the effects of BP-3 on the liver and thyroid using morphological and biochemical approaches.2. Adult male zebrafish were randomly assigned to three groups, each with three repetitions (n = 10 per group): water control, solvent control (0.01% ethanol), and 1 μg/L of BP-3, using a static exposure system for 96 hours. After the experiment, histopathological analyses of the liver and thyroid were performed, along with histochemical analyses (glycogen) and biochemical evaluations of the antioxidant enzymes Superoxide Dismutase (SOD) and Catalase (CAT).3. Exposure to BP-3 resulted in significant histopathological changes in the liver of Danio rerio, increasing the frequency of circulatory disturbances, progressive changes, inflammatory responses, and regressive changes. On the other hand, the thyroid gland did not show any morphological changes during exposure to BP-3, maintaining its typical structure with follicles. There was a significant increase in SOD activity, while CAT showed no changes after 96 hours of exposure.4. The results obtained demonstrate that exposure to BP-3 causes significant morphophysiological changes in the liver of D. rerio, highlighting not only the negative impacts on the health of these organisms but also the ecotoxicological potential of the substance and its consequences for aquatic biota in contaminated environments.

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来源期刊
Xenobiotica
Xenobiotica 医学-毒理学
CiteScore
3.80
自引率
5.60%
发文量
96
审稿时长
2 months
期刊介绍: Xenobiotica covers seven main areas, including:General Xenobiochemistry, including in vitro studies concerned with the metabolism, disposition and excretion of drugs, and other xenobiotics, as well as the structure, function and regulation of associated enzymesClinical Pharmacokinetics and Metabolism, covering the pharmacokinetics and absorption, distribution, metabolism and excretion of drugs and other xenobiotics in manAnimal Pharmacokinetics and Metabolism, covering the pharmacokinetics, and absorption, distribution, metabolism and excretion of drugs and other xenobiotics in animalsPharmacogenetics, defined as the identification and functional characterisation of polymorphic genes that encode xenobiotic metabolising enzymes and transporters that may result in altered enzymatic, cellular and clinical responses to xenobioticsMolecular Toxicology, concerning the mechanisms of toxicity and the study of toxicology of xenobiotics at the molecular levelXenobiotic Transporters, concerned with all aspects of the carrier proteins involved in the movement of xenobiotics into and out of cells, and their impact on pharmacokinetic behaviour in animals and manTopics in Xenobiochemistry, in the form of reviews and commentaries are primarily intended to be a critical analysis of the issue, wherein the author offers opinions on the relevance of data or of a particular experimental approach or methodology
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