日本年轻女性总体队列中抗穆勒氏管激素水平与多囊卵巢综合征之间的关系。

IF 2.7 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Reproductive Medicine and Biology Pub Date : 2024-11-11 eCollection Date: 2024-01-01 DOI:10.1002/rmb2.12615

Natsuki Miyake, Satoko Osuka, Isao Ohsawa, Takashi Tonoike, Tomoko Uno, Kazuo Tsuzuki, Bayasula, Reina Sonehara, Ayako Muraoka, Tomoko Nakamura, Maki Goto, Akira Iwase, Hiroaki Kajiyama

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引用次数: 0

摘要

目的：多囊卵巢综合征（PCOS）对女性的影响很大。本研究调查了血清抗缪勒氏管激素（AMH）水平与月经周期紊乱之间的关系，以及AMH对日本年轻女性多囊卵巢综合征的影响：方法：我们在 2014 年至 2020 年间测量了日本两所大学 528 名健康女学生的血清 AMH 水平。我们研究了血清 AMH 水平与激素水平、月经周期和体重指数之间的关系：结果：AMH水平的平均值（±标准差）为4.78±2.88纳克/毫升。月经不调妇女的血清 AMH 与黄体生成素（LH）或 LH/卵泡刺激素（FSH）水平之间存在相关性（LH：r = 0.542，p r = 0.584，p 结论：血清 AMH 与黄体生成素（LH）或 LH/卵泡刺激素（FSH）水平之间存在相关性：血清 AMH 可在每年的健康检查中进行测量，它可能是对患有多囊卵巢综合征的妇女进行早期和弧形诊断及干预的有用生物标志物。

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Association between anti-Müllerian hormone levels and polycystic ovary syndrome in a general cohort of young women in Japan.

Purpose: Polycystic ovary syndrome (PCOS) significantly affects women. This study investigated the association between serum anti-Müllerian hormone (AMH) levels and menstrual cycle disorders, and AMH for PCOS in a general cohort of young Japanese women.

Methods: We measured serum AMH levels in 528 healthy female students at two universities in Japan between 2014 and 2020. We investigated the association between serum AMH levels and hormone levels, menstrual cycle, and body mass index.

Results: The mean (±standard deviation) AMH level was 4.78 ± 2.88 ng/mL. Correlations were observed between serum AMH and luteinizing hormone (LH) or LH/follicle-stimulating hormone (FSH) levels in women with irregular menstruation (LH: r = 0.542, p < 0.001; LH/FSH: r = 0.584, p < 0.001). The optimal serum AMH cutoff value that predicted LH ≥7.1 IU/L and LH/FSH ≥1.21 (PCOS diagnostic criteria revised by Japan Society of Obstetrics and Gynecology) in women with menstrual irregularities was 5.30 ng/mL (area under the curve: 0.815, sensitivity: 84.2%, specificity: 70.3%).

Conclusions: Serum AMH can be measured during annual health checkups and may be a useful biomarker for early and arcuate diagnosis and intervention in women with PCOS.

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来源期刊

Reproductive Medicine and Biology Multiple-

CiteScore

5.70

自引率

5.90%

发文量

审稿时长

20 weeks

期刊介绍： Reproductive Medicine and Biology (RMB) is the official English journal of the Japan Society for Reproductive Medicine, the Japan Society of Fertilization and Implantation, the Japan Society of Andrology, and publishes original research articles that report new findings or concepts in all aspects of reproductive phenomena in all kinds of mammals. Papers in any of the following fields will be considered: andrology, endocrinology, oncology, immunology, genetics, function of gonads and genital tracts, erectile dysfunction, gametogenesis, function of accessory sex organs, fertilization, embryogenesis, embryo manipulation, pregnancy, implantation, ontogenesis, infectious disease, contraception, etc.