抗菌肽：机理、表达和优化策略。

IF 4.4 2区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Probiotics and Antimicrobial Proteins Pub Date : 2024-11-11 DOI:10.1007/s12602-024-10391-4

Huabiao Miao, Lu Wang, Qian Wu, Zunxi Huang

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引用次数: 0

摘要

抗菌肽（AMPs）因其广谱抗菌特性和不易产生微生物抗药性而备受青睐。然而，抗菌肽产量低、提取工艺复杂，已成为大规模工业应用和科学研究的瓶颈。微生物重组生产可能是获得大量 AMPs 的最经济、最有效的方法。本文回顾了其机理，总结了微生物重组生产的现状，重点探讨了提高 AMPs 产率和活性的策略，以期为其大规模生产提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Antimicrobial Peptides: Mechanism, Expressions, and Optimization Strategies.

Antimicrobial peptides (AMPs) are favoured because of their broad-spectrum antimicrobial properties and because they do not easily develop microbial resistance. However, the low yield and difficult extraction processes of AMPs have become bottlenecks in large-scale industrial applications and scientific research. Microbial recombinant production may be the most economical and effective method of obtaining AMPs in large quantities. In this paper, we review the mechanism, summarize the current status of microbial recombinant production, and focus on strategies to improve the yield and activity of AMPs, in order to provide a reference for their large-scale production.

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来源期刊

Probiotics and Antimicrobial Proteins BIOTECHNOLOGY & APPLIED MICROBIOLOGYMICROB-MICROBIOLOGY

CiteScore

11.30

自引率

6.10%

发文量

140

期刊介绍： Probiotics and Antimicrobial Proteins publishes reviews, original articles, letters and short notes and technical/methodological communications aimed at advancing fundamental knowledge and exploration of the applications of probiotics, natural antimicrobial proteins and their derivatives in biomedical, agricultural, veterinary, food, and cosmetic products. The Journal welcomes fundamental research articles and reports on applications of these microorganisms and substances, and encourages structural studies and studies that correlate the structure and functional properties of antimicrobial proteins.