叶黄素--一种多功能类胡萝卜素：对神经保护潜力的见解和最新进展。

IF 6.7 1区医学 Q1 CHEMISTRY, MEDICINAL

Phytomedicine Pub Date : 2024-10-31 DOI:10.1016/j.phymed.2024.156185

Megha Jayakanthan , Janani Manochkumar , Thomas Efferth , Siva Ramamoorthy

{"title":"叶黄素--一种多功能类胡萝卜素：对神经保护潜力的见解和最新进展。","authors":"Megha Jayakanthan , Janani Manochkumar , Thomas Efferth , Siva Ramamoorthy","doi":"10.1016/j.phymed.2024.156185","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Neurodegenerative diseases (NDDs) are a diverse group of neurological disorders with progressive neuronal loss at specific brain regions, leading to impaired cognitive functioning, loss of neuroplasticity, severe neurological impairment, and dementia. The incidence of neurodegenerative diseases is increasing at an alarming rate with current treatments struggling to barely prolong the inevitable. The desperation to discover a therapeutic agent to treat neurodegenerative diseases and to aid in the process of healthy recovery has opened a gateway into natural pigments.</div></div><div><h3>Hypothesis</h3><div>The xanthophyll pigment lutein may bear the potential as a therapeutic agent against NDDs.</div></div><div><h3>Results</h3><div>Lutein plays an important role in brain development, cognitive functioning, and improving neuroplasticity. <em>In vitro</em> and <em>in vivo</em> studies revealed the neuroprotective properties of lutein against NDDs such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and cerebral ischemia. The neuroprotective effect of lutein is evidenced by the reduction of free radicals and the simultaneous strengthening of the endogenous antioxidant systems by activating the NRF-2/ERK/AKT pathway. Further, it effectively suppressed mitochondrial aberrations, excitotoxicity, overaccumulation of metals, and its resultant complications. The immunomodulatory activity of lutein prevents neuroinflammation by hindering NF-κB nuclear translocation, regulation of NIK/IKK, PI3K/AKT, MAPK/ERK, JNK pathways, and ICAM-1 downregulation. Lutein also rescued the dysregulated cholinergic system and resolved memory defects. Along with its neuroprotective properties, lutein also improved neuroplasticity by enabling neurogenesis through increased GAP-43, NCAM, and BDNF levels.</div></div><div><h3>Conclusion</h3><div>Lutein exhibits strong neuroprotective activities against various NDDs. Though the investigations are in the exploratory phase, this review presents the consolidation of scattered evidence of the neuroprotective properties of lutein and urges its further exploration in clinical studies.</div></div>","PeriodicalId":20212,"journal":{"name":"Phytomedicine","volume":"135 ","pages":"Article 156185"},"PeriodicalIF":6.7000,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Lutein, a versatile carotenoid: Insight on neuroprotective potential and recent advances\",\"authors\":\"Megha Jayakanthan , Janani Manochkumar , Thomas Efferth , Siva Ramamoorthy\",\"doi\":\"10.1016/j.phymed.2024.156185\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Neurodegenerative diseases (NDDs) are a diverse group of neurological disorders with progressive neuronal loss at specific brain regions, leading to impaired cognitive functioning, loss of neuroplasticity, severe neurological impairment, and dementia. The incidence of neurodegenerative diseases is increasing at an alarming rate with current treatments struggling to barely prolong the inevitable. The desperation to discover a therapeutic agent to treat neurodegenerative diseases and to aid in the process of healthy recovery has opened a gateway into natural pigments.</div></div><div><h3>Hypothesis</h3><div>The xanthophyll pigment lutein may bear the potential as a therapeutic agent against NDDs.</div></div><div><h3>Results</h3><div>Lutein plays an important role in brain development, cognitive functioning, and improving neuroplasticity. <em>In vitro</em> and <em>in vivo</em> studies revealed the neuroprotective properties of lutein against NDDs such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and cerebral ischemia. The neuroprotective effect of lutein is evidenced by the reduction of free radicals and the simultaneous strengthening of the endogenous antioxidant systems by activating the NRF-2/ERK/AKT pathway. Further, it effectively suppressed mitochondrial aberrations, excitotoxicity, overaccumulation of metals, and its resultant complications. The immunomodulatory activity of lutein prevents neuroinflammation by hindering NF-κB nuclear translocation, regulation of NIK/IKK, PI3K/AKT, MAPK/ERK, JNK pathways, and ICAM-1 downregulation. Lutein also rescued the dysregulated cholinergic system and resolved memory defects. Along with its neuroprotective properties, lutein also improved neuroplasticity by enabling neurogenesis through increased GAP-43, NCAM, and BDNF levels.</div></div><div><h3>Conclusion</h3><div>Lutein exhibits strong neuroprotective activities against various NDDs. Though the investigations are in the exploratory phase, this review presents the consolidation of scattered evidence of the neuroprotective properties of lutein and urges its further exploration in clinical studies.</div></div>\",\"PeriodicalId\":20212,\"journal\":{\"name\":\"Phytomedicine\",\"volume\":\"135 \",\"pages\":\"Article 156185\"},\"PeriodicalIF\":6.7000,\"publicationDate\":\"2024-10-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytomedicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0944711324008420\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytomedicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0944711324008420","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

摘要

背景：神经退行性疾病（NDDs）是一类神经系统疾病，其特征是特定脑区的神经元逐渐丧失，导致认知功能受损、神经可塑性丧失、严重神经功能损伤和痴呆。神经退行性疾病的发病率正以惊人的速度增长，而目前的治疗方法只能勉强延长不可避免的病程。人们迫切希望找到一种治疗剂来治疗神经退行性疾病并帮助健康恢复，这就为天然色素打开了大门：假设：叶黄素可能具有治疗神经退行性疾病的潜力：叶黄素在大脑发育、认知功能和改善神经可塑性方面发挥着重要作用。体外和体内研究显示，叶黄素对阿尔茨海默病、帕金森病、亨廷顿病和脑缺血等 NDD 具有神经保护作用。叶黄素的神经保护作用体现在通过激活 NRF-2/ERK/AKT 通路减少自由基并同时加强内源性抗氧化系统。此外，它还能有效抑制线粒体畸变、兴奋性毒性、金属过度积累及其导致的并发症。叶黄素的免疫调节活性通过阻碍 NF-κB 核转位、调节 NIK/IKK、PI3K/AKT、MAPK/ERK、JNK 通路和下调 ICAM-1 来防止神经炎症。叶黄素还能挽救失调的胆碱能系统，解决记忆缺陷问题。叶黄素除了具有神经保护特性外，还能通过提高 GAP-43、NCAM 和 BDNF 水平促进神经发生，从而改善神经可塑性：叶黄素对各种 NDD 具有很强的神经保护作用。尽管研究还处于探索阶段，但本综述整合了叶黄素神经保护特性的零散证据，并敦促在临床研究中进一步探索叶黄素的神经保护特性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Lutein, a versatile carotenoid: Insight on neuroprotective potential and recent advances

查看原文本刊更多论文

Lutein, a versatile carotenoid: Insight on neuroprotective potential and recent advances

Background

Neurodegenerative diseases (NDDs) are a diverse group of neurological disorders with progressive neuronal loss at specific brain regions, leading to impaired cognitive functioning, loss of neuroplasticity, severe neurological impairment, and dementia. The incidence of neurodegenerative diseases is increasing at an alarming rate with current treatments struggling to barely prolong the inevitable. The desperation to discover a therapeutic agent to treat neurodegenerative diseases and to aid in the process of healthy recovery has opened a gateway into natural pigments.

Hypothesis

The xanthophyll pigment lutein may bear the potential as a therapeutic agent against NDDs.

Results

Lutein plays an important role in brain development, cognitive functioning, and improving neuroplasticity. In vitro and in vivo studies revealed the neuroprotective properties of lutein against NDDs such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and cerebral ischemia. The neuroprotective effect of lutein is evidenced by the reduction of free radicals and the simultaneous strengthening of the endogenous antioxidant systems by activating the NRF-2/ERK/AKT pathway. Further, it effectively suppressed mitochondrial aberrations, excitotoxicity, overaccumulation of metals, and its resultant complications. The immunomodulatory activity of lutein prevents neuroinflammation by hindering NF-κB nuclear translocation, regulation of NIK/IKK, PI3K/AKT, MAPK/ERK, JNK pathways, and ICAM-1 downregulation. Lutein also rescued the dysregulated cholinergic system and resolved memory defects. Along with its neuroprotective properties, lutein also improved neuroplasticity by enabling neurogenesis through increased GAP-43, NCAM, and BDNF levels.

Conclusion

Lutein exhibits strong neuroprotective activities against various NDDs. Though the investigations are in the exploratory phase, this review presents the consolidation of scattered evidence of the neuroprotective properties of lutein and urges its further exploration in clinical studies.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Phytomedicine 医学-药学

CiteScore

10.30

自引率

5.10%

发文量

670

审稿时长

91 days

期刊介绍： Phytomedicine is a therapy-oriented journal that publishes innovative studies on the efficacy, safety, quality, and mechanisms of action of specified plant extracts, phytopharmaceuticals, and their isolated constituents. This includes clinical, pharmacological, pharmacokinetic, and toxicological studies of herbal medicinal products, preparations, and purified compounds with defined and consistent quality, ensuring reproducible pharmacological activity. Founded in 1994, Phytomedicine aims to focus and stimulate research in this field and establish internationally accepted scientific standards for pharmacological studies, proof of clinical efficacy, and safety of phytomedicines.