基于家庭的在线线段划分测试可检测帕金森病患者的视觉空间疏忽和假性疏忽。

IF 3.1 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders Pub Date : 2024-11-08 DOI:10.1016/j.parkreldis.2024.107195

Louis Albert , Fosco Bernasconi , Jevita Potheegadoo , Olaf Blanke

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引用次数: 0

摘要

简介帕金森病（PD）可能导致认知症状，包括视觉空间注意缺陷，如单侧空间忽略（USN）。虽然有一些证据表明帕金森病患者，尤其是左侧发病的运动症状患者（LPD）存在单侧空间忽视，但以往的研究显示，使用线段分割法进行忽视任务的结果不一致且差异很大，而且没有系统地将LPD与RPD（右侧发病的帕金森病患者）或健康对照组（HC）进行比较：我们设计了一个基于网络的全自动在线线段分割任务，并对一组 170 名 PD 患者（81 名 RPD，66 名 LPD）和 45 名 HC 进行了测试：我们的数据显示：(1) LPD 与 HC 和 RPD 相比，在进行线段划分时存在右倾偏差；(2) HC 和 RPD 都存在右侧假性疏忽。我们的数据还显示：(3) 与主要受影响的一侧无关，帕金森病患者的划线偏差更大：这些数据为帕金森病患者视觉空间感知的系统性变化提供了有力的证据，并为 USN 提供了一种新的在线诊断和监测工具，可在患者家中对其进行评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Home-based online line bisection test detects visuo-spatial neglect and pseudoneglect in Parkinson's disease

Introduction

Parkinson's Disease (PD) may lead to cognitive symptoms, including visuo-spatial attentional deficits such as unilateral spatial neglect (USN). Although there is some evidence for USN in PD patients, especially in those with left-sided onset of motor-symptoms (LPD), previous studies revealed inconsistent and highly variable results in neglect tasks using line bisection and have not systematically compared LPD with RPD (PD patients with right-sided onset) or healthy controls (HC).

Methods

We designed a fully automatized online web-based line bisection task and tested a group of 170 PD patients (81 RPD, 66 LPD) and 45 HC.

Results

Our data reveals (1) a rightward bias on line bisection in LPD compared to HC and RPD, (2) right-sided pseudoneglect in HC as well as RPD. Our data also reveals that (3) PD patients, independent of the primarily affected side, are more variable in their line bisections.

Conclusion

These data provide robust evidence for systematic changes in visuo-spatial perception in PD and present a new online diagnosis and monitoring tool for USN to evaluate patients at their home.

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来源期刊

Parkinsonism & related disorders 医学-临床神经学

CiteScore

6.20

自引率

4.90%

发文量

292

审稿时长

39 days

期刊介绍： Parkinsonism & Related Disorders publishes the results of basic and clinical research contributing to the understanding, diagnosis and treatment of all neurodegenerative syndromes in which Parkinsonism, Essential Tremor or related movement disorders may be a feature. Regular features will include: Review Articles, Point of View articles, Full-length Articles, Short Communications, Case Reports and Letter to the Editor.