浆液性边界卵巢肿瘤的微乳头状形态与低级别浆液性癌（"浸润性种植"）的卵巢外定位风险：系统综述与荟萃分析。

IF 2.9 4区医学 Q2 PATHOLOGY

Pathology, research and practice Pub Date : 2024-11-06 DOI:10.1016/j.prp.2024.155714

Giulia Scaglione , Antonio Travaglino , Antonio Raffone , Angela Santoro , Damiano Arciuolo , Caterina Fulgione , Nicoletta D’Alessandris , Giuseppe Pannone , Belen Padial Urtueta , Nadine Narducci , Francesca Addante , Jvan Casarin , Susanna Ronchi , Eleonora Di Lauro , Stefano La Rosa , Livia Maccio , Frediano Inzani , Gian Franco Zannoni

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引用次数: 0

摘要

在浆液性边界卵巢肿瘤（SBOT）中，微乳头状（MP）模式被认为类似于上皮内低级别浆液性癌（LGSC）。因此，我们有理由假设，与传统的 SBOT 相比，MP-SBOT 更有可能与卵巢外 LGSC 定位（也称为 "浸润性种植"）有关。本研究旨在调查 MP 模式与 SBOT 侵袭性种植之间的潜在关联。研究人员检索了从 2000 年（MP-SBOT 组织学标准公布的年份）到 2023 年的三个电子数据库中所有评估传统 SBOT 与 MP-SBOT 中是否存在浸润性植入物的研究。排除标准为样本量为 2=28 %）。总之，SBOT 中的 MP 模式与卵巢外 LGSC 定位显著相关，支持 MP 模式代表上皮内 LGSC。

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Micropapillary pattern in serous borderline ovarian tumor and the risk of extraovarian localization of low-grade serous carcinoma (‘invasive implants’): A systematic review and meta-analysis

In serous borderline ovarian tumor (SBOT), a micropapillary (MP) pattern has been considered analogous to intraepithelial low-grade serous carcinoma (LGSC). On this account, it is reasonable to hypothesize that MP-SBOT is more likely to be associated with extraovarian LGSC localizations (also referred to as 'invasive implants') compared to conventional SBOT. The aim of this study was to investigate the potential association between a MP pattern and invasive implants in SBOT. Three electronic databases were searched from 2000 (year of publication of histological criteria for MP-SBOT) to 2023 for all studies assessing the presence of invasive implants in conventional SBOT vs MP-SBOT. Exclusion criteria were sample size <20, overlapping patient data, reviews. The association between MP pattern and invasive implants was assessed by using odds ratio (OR), with a significant p-value<0.05. Seven studies with 1766 SBOT were included, out of which 205 (11.5 %) were MP-SBOT, 462 (26 %) had implants and 62 (3.5 %) had invasive implants. A MP pattern was significantly associated with the presence of invasive implants (OR=7.33, 95 % CI 3.61–14.86) (p<0.001), with low heterogeneity among studies (I²=28 %). In conclusion, a MP pattern in SBOT is significantly associated with extraovarian LGSC localization, supporting that it represents intraepithelial LGSC.

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来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.