肺部疾病发病机制中的神经肽或其受体及其治疗潜力。

IF 2.5 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Neuropeptides Pub Date : 2024-11-02 DOI:10.1016/j.npep.2024.102482

Changgen Li , Na Zang , Enmei Liu

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引用次数: 0

摘要

肺部的免疫系统和神经系统之间存在着复杂的相互作用。神经系统感知环境刺激，并通过神经递质将这些信号传递给免疫细胞，这对有效免疫和环境平衡至关重要。神经肽是肺部重要的神经递质，通过直接和间接机制调节免疫反应，影响肺部疾病的发生和发展。在这篇综述中，我们强调了神经肽在肺部疾病病因中的作用及其对肺部疾病的潜在治疗价值。

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Neuropeptides or their receptors in pathogenesis of lung diseases and therapeutic potentials

There are complex interactions between the immune system and the nervous system in the lung. The nervous system perceives environmental stimuli and transmits these signals to immune cells via neurotransmitters, which is essential for effective immunity and environmental balance. Neuropeptides are important neurotransmitters in the lung, where they regulate immune responses through direct and indirect mechanisms, affecting the occurrence and development of lung diseases. In this review, we emphasize the role of neuropeptides in the pathogeneis of lung diseases and their potential therapeutic value for lung diseases.

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来源期刊

Neuropeptides 医学-内分泌学与代谢

CiteScore

5.40

自引率

6.90%

发文量

审稿时长

>12 weeks

期刊介绍： The aim of Neuropeptides is the rapid publication of original research and review articles, dealing with the structure, distribution, actions and functions of peptides in the central and peripheral nervous systems. The explosion of research activity in this field has led to the identification of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The journal provides a unique opportunity of integrating the many disciplines involved in all neuropeptide research. The journal publishes articles on all aspects of the neuropeptide field, with particular emphasis on gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.