Mihai Babotă, Oleg Frumuzachi, Corneliu Tanase, Andrei Mocan
{"title":"补充杨梅素对葡萄糖和脂质代谢的功效：体内小鼠研究的系统回顾和荟萃分析》。","authors":"Mihai Babotă, Oleg Frumuzachi, Corneliu Tanase, Andrei Mocan","doi":"10.3390/nu16213730","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/objectives: </strong>Type 2 diabetes mellitus (T2DM) is a disorder characterized by insulin resistance, hyperglycemia, and dyslipidemia. Myricetin, a flavonoid found in various plants, has shown potential anti-diabetic effects in murine studies. This meta-analysis aimed to evaluate the impact of myricetin supplementation on glucose metabolism and lipid profiles in mouse models of metabolic diseases.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted in accordance with PRISMA guidelines (PROSPERO: CRD42024591569). Studies involving mice with metabolic disease models and exclusively using myricetin supplementation were checked across four databases (Embase, Scopus, PubMed, and WoS) until 23rd September 2024. The primary outcomes assessed were blood glucose (BG), insulin levels, triacylglycerol (TAG), total cholesterol (TC), HDL, and LDL. A random-effects model was applied to estimate standardized mean differences (SMD), and SYRCLE's risk-of-bias tool for animal studies was used.</p><p><strong>Results: </strong>Twenty-one studies with 514 mice met the inclusion criteria. Myricetin supplementation significantly reduced BG (SMD = -1.45, CI: -1.91 to -0.99, <i>p</i> < 0.00001, <i>I</i><sup>2</sup> = 74%), insulin (SMD = -1.78, CI: -2.89 to -0.68, <i>p</i> = 0.002, <i>I</i><sup>2</sup> = 86%), TAG (SMD = -2.60, CI: -3.24 to -1.96, <i>p</i> < 0.00001, <i>I</i><sup>2</sup> = 81%), TC (SMD = -1.86, CI: -2.29 to -1.44, <i>p</i> < 0.00001, <i>I</i><sup>2</sup> = 62%), and LDL (SMD = -2.95, CI: -3.75 to -2.14, <i>p</i> < 0.00001, <i>I</i><sup>2</sup> = 74%). However, the effect on HDL was not statistically significant (SMD = 0.71, CI: -0.01 to 1.43, <i>p</i> = 0.05, <i>I</i><sup>2</sup> = 83%).</p><p><strong>Conclusions: </strong>Myricetin supplementation improved glucose metabolism and lipid profiles in mouse models, suggesting its potential as a therapeutic agent for managing T2DM. However, further research is needed to confirm these findings in human studies.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"16 21","pages":""},"PeriodicalIF":4.8000,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11547919/pdf/","citationCount":"0","resultStr":"{\"title\":\"Efficacy of Myricetin Supplementation on Glucose and Lipid Metabolism: A Systematic Review and Meta-Analysis of In Vivo Mice Studies.\",\"authors\":\"Mihai Babotă, Oleg Frumuzachi, Corneliu Tanase, Andrei Mocan\",\"doi\":\"10.3390/nu16213730\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background/objectives: </strong>Type 2 diabetes mellitus (T2DM) is a disorder characterized by insulin resistance, hyperglycemia, and dyslipidemia. Myricetin, a flavonoid found in various plants, has shown potential anti-diabetic effects in murine studies. This meta-analysis aimed to evaluate the impact of myricetin supplementation on glucose metabolism and lipid profiles in mouse models of metabolic diseases.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted in accordance with PRISMA guidelines (PROSPERO: CRD42024591569). Studies involving mice with metabolic disease models and exclusively using myricetin supplementation were checked across four databases (Embase, Scopus, PubMed, and WoS) until 23rd September 2024. The primary outcomes assessed were blood glucose (BG), insulin levels, triacylglycerol (TAG), total cholesterol (TC), HDL, and LDL. A random-effects model was applied to estimate standardized mean differences (SMD), and SYRCLE's risk-of-bias tool for animal studies was used.</p><p><strong>Results: </strong>Twenty-one studies with 514 mice met the inclusion criteria. Myricetin supplementation significantly reduced BG (SMD = -1.45, CI: -1.91 to -0.99, <i>p</i> < 0.00001, <i>I</i><sup>2</sup> = 74%), insulin (SMD = -1.78, CI: -2.89 to -0.68, <i>p</i> = 0.002, <i>I</i><sup>2</sup> = 86%), TAG (SMD = -2.60, CI: -3.24 to -1.96, <i>p</i> < 0.00001, <i>I</i><sup>2</sup> = 81%), TC (SMD = -1.86, CI: -2.29 to -1.44, <i>p</i> < 0.00001, <i>I</i><sup>2</sup> = 62%), and LDL (SMD = -2.95, CI: -3.75 to -2.14, <i>p</i> < 0.00001, <i>I</i><sup>2</sup> = 74%). However, the effect on HDL was not statistically significant (SMD = 0.71, CI: -0.01 to 1.43, <i>p</i> = 0.05, <i>I</i><sup>2</sup> = 83%).</p><p><strong>Conclusions: </strong>Myricetin supplementation improved glucose metabolism and lipid profiles in mouse models, suggesting its potential as a therapeutic agent for managing T2DM. 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Efficacy of Myricetin Supplementation on Glucose and Lipid Metabolism: A Systematic Review and Meta-Analysis of In Vivo Mice Studies.
Background/objectives: Type 2 diabetes mellitus (T2DM) is a disorder characterized by insulin resistance, hyperglycemia, and dyslipidemia. Myricetin, a flavonoid found in various plants, has shown potential anti-diabetic effects in murine studies. This meta-analysis aimed to evaluate the impact of myricetin supplementation on glucose metabolism and lipid profiles in mouse models of metabolic diseases.
Methods: A systematic review and meta-analysis were conducted in accordance with PRISMA guidelines (PROSPERO: CRD42024591569). Studies involving mice with metabolic disease models and exclusively using myricetin supplementation were checked across four databases (Embase, Scopus, PubMed, and WoS) until 23rd September 2024. The primary outcomes assessed were blood glucose (BG), insulin levels, triacylglycerol (TAG), total cholesterol (TC), HDL, and LDL. A random-effects model was applied to estimate standardized mean differences (SMD), and SYRCLE's risk-of-bias tool for animal studies was used.
Results: Twenty-one studies with 514 mice met the inclusion criteria. Myricetin supplementation significantly reduced BG (SMD = -1.45, CI: -1.91 to -0.99, p < 0.00001, I2 = 74%), insulin (SMD = -1.78, CI: -2.89 to -0.68, p = 0.002, I2 = 86%), TAG (SMD = -2.60, CI: -3.24 to -1.96, p < 0.00001, I2 = 81%), TC (SMD = -1.86, CI: -2.29 to -1.44, p < 0.00001, I2 = 62%), and LDL (SMD = -2.95, CI: -3.75 to -2.14, p < 0.00001, I2 = 74%). However, the effect on HDL was not statistically significant (SMD = 0.71, CI: -0.01 to 1.43, p = 0.05, I2 = 83%).
Conclusions: Myricetin supplementation improved glucose metabolism and lipid profiles in mouse models, suggesting its potential as a therapeutic agent for managing T2DM. However, further research is needed to confirm these findings in human studies.
期刊介绍：
Nutrients (ISSN 2072-6643) is an international, peer-reviewed open access advanced forum for studies related to Human Nutrition. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
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