乳化与缺血性中风:研究进展和潜在关系。

IF 4.6 2区 医学 Q1 NEUROSCIENCES
Jingyuan Zhang, Feng Lin, Yue Xu, Jiaxin Sun, Lei Zhang, Wenli Chen
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引用次数: 0

摘要

缺血性中风是由脑血流中断引起的,是导致全球死亡和残疾的主要原因。在理解中风的病理生理学和缺血性损伤的基本机制方面取得了重大进展。据报道,乳化作为一种新发现的翻译后修饰,参与了多个生理和病理过程。然而,有关乳化与缺血性中风的研究却很少。本综述总结了目前蛋白质乳化在其他疾病或正常生理过程中的功能,并探讨了其与缺血性脑卒中的病理生理过程和修复机制的潜在联系。我们提出,神经炎症、代谢调控、信使 RNA 翻译调控、血管生成和神经再生可能是连接乳化与缺血性脑卒中的桥梁。我们的研究为理解蛋白质乳化在缺血性中风的病理生理过程中的作用提供了一个新的视角。乳化作用可能是缺血性中风药物开发的一个有前景的靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lactylation and Ischemic Stroke: Research Progress and Potential Relationship.

Ischemic stroke is caused by interrupted cerebral blood flow and is a leading cause of mortality and disability worldwide. Significant advancements have been achieved in comprehending the pathophysiology of stroke and the fundamental mechanisms responsible for ischemic damage. Lactylation, as a newly discovered post-translational modification, has been reported to participate in several physiological and pathological processes. However, research on lactylation and ischemic stroke is scarce. This review summarized the current function of protein lactylation in other diseases or normal physiological processes and explored their potential link with the pathophysiological process and the reparative mechanism of ischemic stroke. We proposed that neuroinflammation, regulation of metabolism, regulation of messenger RNA translation, angiogenesis, and neurogenesis might be the bridge linking lactylation and ischemic stroke. Our study provided a novel perspective for comprehending the role of protein lactylation in the pathophysiological processes underlying ischemic stroke. Lactylation might be a promising target in drug development of ischemic stroke.

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来源期刊
Molecular Neurobiology
Molecular Neurobiology 医学-神经科学
CiteScore
9.00
自引率
2.00%
发文量
480
审稿时长
1 months
期刊介绍: Molecular Neurobiology is an exciting journal for neuroscientists needing to stay in close touch with progress at the forefront of molecular brain research today. It is an especially important periodical for graduate students and "postdocs," specifically designed to synthesize and critically assess research trends for all neuroscientists hoping to stay active at the cutting edge of this dramatically developing area. This journal has proven to be crucial in departmental libraries, serving as essential reading for every committed neuroscientist who is striving to keep abreast of all rapid developments in a forefront field. Most recent significant advances in experimental and clinical neuroscience have been occurring at the molecular level. Until now, there has been no journal devoted to looking closely at this fragmented literature in a critical, coherent fashion. Each submission is thoroughly analyzed by scientists and clinicians internationally renowned for their special competence in the areas treated.
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