异丁酸盐通过抑制炎症和氧化应激对DSS诱导的结肠炎中的肝损伤具有保护作用。

IF 3.3 2区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Journal of the Science of Food and Agriculture Pub Date : 2024-11-14 DOI:10.1002/jsfa.14021

Haiyang Liu, Yongqing Du, Zhengyi Wang, Xiuyu Fang, Haowen Sun, Feng Gao, Tingting Shang, Baoming Shi

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引用次数: 0

摘要

背景：据报道，短链脂肪酸具有抗炎和抗氧化功能；异丁酸作为一种短链脂肪酸，对葡聚糖硫酸钠（DSS）诱导的结肠炎肝损伤是否具有保护作用及其分子机制尚不清楚。本研究使用右旋糖酐硫酸钠诱导仔猪结肠炎模型的肝损伤，希望通过提前饲喂异丁烯酸钠来预防和减轻右旋糖酐硫酸钠诱导的肝损伤：结果表明：异丁烯酸钠可恢复DSS诱导的肝脏组织病理变化，抑制toll样受体4/髓系分化初级反应88/核因子卡巴-B信号通路的激活，进而减少DSS诱导的促炎细胞因子肿瘤坏死因子-α、白细胞介素1β和白细胞介素6的释放，减轻炎症反应。此外，我们还发现异丁酸钠可通过维持线粒体功能的降低，起到抗氧化和减少细胞凋亡的作用：总之，异丁酸钠对 DSS 诱导的结肠炎的肝损伤具有预防和保护作用。异丁酸钠在治疗溃疡性结肠炎引起的肝损伤方面具有潜在的应用前景。© 2024 化学工业协会。

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Isobutyrate exerts a protective effect against liver injury in a DSS-induced colitis by inhibiting inflammation and oxidative stress.

Background: Short-chain fatty acids have been reported to have anti-inflammatory and antioxidant functions; whether isobutyrate, a short-chain fatty acid, is protective against liver injury in a dextran sodium sulfate (DSS)-induced colitis and its molecular mechanism is unknown. In this study, DSS was used to induce a liver injury from a colitis model in piglets, which was expected to prevent and alleviate DSS-induced liver injury by feeding sodium isobutyrate in advance.

Results: The results showed that sodium isobutyrate could restore DSS-induced histopathological changes in the liver, inhibit the activation of the toll-like receptor 4/myeloid differentiation primary response 88/nuclear factor kappa-B signaling pathway, and then reduce the DSS-induced release of pro-inflammatory cytokines tumor necrosis factor-α, interleukin 1β, and interleukin 6, reducing inflammatory response. Moreover, we found that sodium isobutyrate could play an antioxidant and apoptosis-reducing role by maintaining reduced mitochondrial function.

Conclusion: In conclusion, sodium isobutyrate has a preventive and protective effect on liver injury in a DSS-induced colitis. There is a potential application prospect for it in treating ulcerative-colitis-induced liver injuries. © 2024 Society of Chemical Industry.

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来源期刊

Journal of the Science of Food and Agriculture 工程技术-农业综合

CiteScore

8.10

自引率

4.90%

发文量

634

审稿时长

3.1 months

期刊介绍： The Journal of the Science of Food and Agriculture publishes peer-reviewed original research, reviews, mini-reviews, perspectives and spotlights in these areas, with particular emphasis on interdisciplinary studies at the agriculture/ food interface. Published for SCI by John Wiley & Sons Ltd. SCI (Society of Chemical Industry) is a unique international forum where science meets business on independent, impartial ground. Anyone can join and current Members include consumers, business people, environmentalists, industrialists, farmers, and researchers. The Society offers a chance to share information between sectors as diverse as food and agriculture, pharmaceuticals, biotechnology, materials, chemicals, environmental science and safety. As well as organising educational events, SCI awards a number of prestigious honours and scholarships each year, publishes peer-reviewed journals, and provides Members with news from their sectors in the respected magazine, Chemistry & Industry . Originally established in London in 1881 and in New York in 1894, SCI is a registered charity with Members in over 70 countries.