肺炎病毒的病毒载量：与合并感染率和疾病严重程度的相关性。

IF 6.8 3区医学 Q1 VIROLOGY

Journal of Medical Virology Pub Date : 2024-11-12 DOI:10.1002/jmv.70054

Sarah Talah, Julie Carbonneau, Marie-Eve Hamelin, Rodica Gilca, Guy Boivin

{"title":"肺炎病毒的病毒载量：与合并感染率和疾病严重程度的相关性。","authors":"Sarah Talah, Julie Carbonneau, Marie-Eve Hamelin, Rodica Gilca, Guy Boivin","doi":"10.1002/jmv.70054","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>We looked at the interactions between viral loads, coinfection rates and disease severity for children infected with two pneumoviruses: human metapneumovirus (HMPV) and respiratory syncytial virus (RSV). The HMPV RNA load in nasopharyngeal swabs of hospitalized children was significantly higher in mono-infections compared to coinfections but this was not the case for RSV, which could be explained by different innate immune responses. Also, the viral load of neither of the two viruses was associated with disease severity although RSV-infected children had higher severity scores than HMPV-infected children.</p>\n </div>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"96 11","pages":""},"PeriodicalIF":6.8000,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Viral Loads of Pneumoviruses: Correlation With Coinfection Rates and Disease Severity\",\"authors\":\"Sarah Talah, Julie Carbonneau, Marie-Eve Hamelin, Rodica Gilca, Guy Boivin\",\"doi\":\"10.1002/jmv.70054\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>We looked at the interactions between viral loads, coinfection rates and disease severity for children infected with two pneumoviruses: human metapneumovirus (HMPV) and respiratory syncytial virus (RSV). The HMPV RNA load in nasopharyngeal swabs of hospitalized children was significantly higher in mono-infections compared to coinfections but this was not the case for RSV, which could be explained by different innate immune responses. Also, the viral load of neither of the two viruses was associated with disease severity although RSV-infected children had higher severity scores than HMPV-infected children.</p>\\n </div>\",\"PeriodicalId\":16354,\"journal\":{\"name\":\"Journal of Medical Virology\",\"volume\":\"96 11\",\"pages\":\"\"},\"PeriodicalIF\":6.8000,\"publicationDate\":\"2024-11-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Medical Virology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/jmv.70054\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"VIROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medical Virology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jmv.70054","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"VIROLOGY","Score":null,"Total":0}

引用次数: 0

摘要

我们研究了感染人类偏肺病毒（HMPV）和呼吸道合胞病毒（RSV）这两种肺炎病毒的儿童的病毒载量、合并感染率和疾病严重程度之间的相互作用。住院儿童鼻咽拭子中的 HMPV RNA 载量在单感染者中明显高于合并感染者，但 RSV 的情况并非如此，这可能是由于先天性免疫反应不同造成的。此外，两种病毒的病毒载量都与疾病的严重程度无关，尽管感染 RSV 的儿童比感染 HMPV 的儿童的严重程度评分更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Viral Loads of Pneumoviruses: Correlation With Coinfection Rates and Disease Severity

We looked at the interactions between viral loads, coinfection rates and disease severity for children infected with two pneumoviruses: human metapneumovirus (HMPV) and respiratory syncytial virus (RSV). The HMPV RNA load in nasopharyngeal swabs of hospitalized children was significantly higher in mono-infections compared to coinfections but this was not the case for RSV, which could be explained by different innate immune responses. Also, the viral load of neither of the two viruses was associated with disease severity although RSV-infected children had higher severity scores than HMPV-infected children.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Medical Virology 医学-病毒学

CiteScore

23.20

自引率

2.40%

发文量

777

审稿时长

1 months

期刊介绍： The Journal of Medical Virology focuses on publishing original scientific papers on both basic and applied research related to viruses that affect humans. The journal publishes reports covering a wide range of topics, including the characterization, diagnosis, epidemiology, immunology, and pathogenesis of human virus infections. It also includes studies on virus morphology, genetics, replication, and interactions with host cells. The intended readership of the journal includes virologists, microbiologists, immunologists, infectious disease specialists, diagnostic laboratory technologists, epidemiologists, hematologists, and cell biologists. The Journal of Medical Virology is indexed and abstracted in various databases, including Abstracts in Anthropology (Sage), CABI, AgBiotech News & Information, National Agricultural Library, Biological Abstracts, Embase, Global Health, Web of Science, Veterinary Bulletin, and others.