肿瘤相关巨噬细胞在结直肠肝转移中的生物学作用和临床治疗应用

IF 4.2 2区医学 Q2 IMMUNOLOGY

Journal of Inflammation Research Pub Date : 2024-11-07 eCollection Date: 2024-01-01 DOI:10.2147/JIR.S493656

Shenghao Li, Liyuan Hao, Xiaoyu Hu

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引用次数: 0

摘要

结肠直肠癌（CRC）通常会转移到肝脏，这给临床带来了巨大挑战。肿瘤相关巨噬细胞（TAMs）是TME中的关键角色，通过分泌各种趋化因子、生长因子和细胞因子，在促进CRC转移方面发挥着重要作用。这篇综述不仅旨在加深我们对 TAMs 在 CRC 进展和转移中的功能的了解，而且还探讨了解决结直肠肝转移（CLM）这一临床问题的创新治疗策略。通过靶向 TAMs，我们或许能开发出更有效的治疗方法，为罹患这种毁灭性疾病的患者带来希望。

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Biological Roles and Clinical Therapeutic Applications of Tumor-Associated Macrophages in Colorectal Liver Metastasis.

Colorectal cancer (CRC) commonly metastasizes to the liver, and this poses a significant clinical challenge. Tumor-associated macrophages (TAMs), key players within the TME, play a significant role in promoting CRC metastasis by secreting various chemokines, growth factors, and cytokines. This review not only aims to enhance our knowledge of TAMs' functions in CRC progression and metastasis but also examines innovative therapeutic strategies to address the clinical problem of colorectal liver metastasis (CLM). By targeting TAMs, we may be able to develop more effective treatments and offer hope to patients suffering from this devastating disease.

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来源期刊

Journal of Inflammation Research Immunology and Microbiology-Immunology

CiteScore

6.10

自引率

2.20%

发文量

658

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal that welcomes laboratory and clinical findings on the molecular basis, cell biology and pharmacology of inflammation.