认知障碍和小血管疾病患者淀粉样蛋白-β沉积的标志物和血管周围空间扩大的负担。

IF 3.4 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2024-11-11 DOI:10.1177/13872877241296012

Ana Sofia Costa, Lieza G Exalto, Wiesje M van der Flier, Charlotte E Teunissen, Frederik Barkhof, Hugo J Kuijf, Geert Jan Biessels

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引用次数: 0

摘要

核磁共振成像（MRI）可见的血管周围间隙增大（EPVS）在认知障碍患者中很常见，可能与阿尔茨海默病（AD）和脑淀粉样血管病（CAA）有关。在一项对记忆门诊患者（n = 450；平均年龄 66.5 ± 7.45，45.8% 为女性）的研究中，我们调查了 CSF 淀粉样蛋白-β（Aβ）1-42（AD 生物标记物）和严格脑叶微出血（CAA 标记物）与半卵圆中心 EPVS（CSO-EPVS）的关系。年龄对照分析表明，严重的CSO-EPVS与Aβ状态有关（几率比[OR] = 1.51，95%CI = 1.02-2.24），但与严格的脑叶微出血无关（OR = 1.39，95%CI = 0.92-2.11），Aβ状态与微出血之间没有显著的交互作用。这意味着，在这种情况下，重度 CSO-EPVS 并不是 CAA 的特异性指标。

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Markers of amyloid-β deposition and burden of enlarged perivascular spaces in patients with cognitive impairment and small vessel disease.

MRI-visible enlarged perivascular spaces (EPVS) are common in patients with cognitive impairment and possibly linked to Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA). In a study of memory clinic patients (n = 450; mean age 66.5 ± 7.45, 45.8% female), we investigated CSF amyloid-β (Aβ)_1-42 (AD biomarker) and strictly lobar microbleeds (CAA marker) in relation to centrum semiovale EPVS (CSO-EPVS). Age-controlled analyses showed that severe CSO-EPVS associated with Aβ status (odds ratio [OR] = 1.51, 95%CI = 1.02-2.24), but not strictly lobar microbleeds (OR = 1.39, 95%CI = 0.92-2.11), with no significant Aβ status and microbleeds interaction. This implies that in this setting, severe CSO-EPVS is not a specific indicator of CAA.

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.