2021 年中国广西人感染甲型禽流感 H5N6 病毒的流行病学和遗传学特征。

IF 4.8 2区医学 Q1 INFECTIOUS DISEASES

International Journal of Infectious Diseases Pub Date : 2024-11-07 DOI:10.1016/j.ijid.2024.107288

Fuyin Bi , Weitao He , Ning Kang , Hang Huang , Huafeng Chen , Zhenli Liang , Yu Ju , Jun Zeng , Jing Wang

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引用次数: 0

摘要

禽流感（AI）H5N6已取代H5N1成为主要毒株，病例数量的增加和复杂的重组模式对人类健康构成重大威胁。本研究从广西全国应报传染病监测项目（NSNIDP）中收集了人感染禽流感H5N6病例数据，并使用MEGA软件与GISAID数据库中已发表的参考毒株进行系统发育分析。2021年1月1日至12月31日，广西共报告11例人感染禽流感H5N6病例。所有HA基因均属于2.3.4.4支系，只有一种病毒属于2.3.4.4h支系，其余病毒属于2.3.4.4b支系。对这些基因进行了系统进化分析，在 HA 基因、M1 蛋白和 NS1 蛋白中发现了一些替换。据观察，广西病毒与家禽源甲型流感病毒关系密切。鉴于活禽市场和散养家禽的污染，禽流感 H5N6 的变种和基因型将不断出现，因此，加强监测对防范大流行至关重要。

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Epidemiological and genetic characterization of human infection with avian influenza AI H5N6 virus in Guangxi, China, 2021

Objectives

Avian influenza (AI) H5N6 has replaced H5N1 as the predominant strain, and the increasing number of cases and complex recombination patterns pose significant threats to human health.

Methods

The data were collected on human cases of AI H5N6 from the National Surveillance of Notifiable Infectious Disease Programme in Guangxi and used MEGA software to conduct phylogenetic analysis with published reference strains obtained from the GISAID database.

Results

Between January 1 and December 31, 2021, 11 cases of human AI H5N6 infection were reported in Guangxi. All HA genes belonged to clade 2.3.4.4, with only one virus belonging to 2.3.4.4h and the remaining viruses falling into 2.3.4.4b. Phylogenetic analysis of the genes was conducted, and some substitutions were detected in the HA gene, M1 protein, and NS1 protein. A close relationship between Guangxi viruses and AI viruses of poultry origin has been observed.

Conclusion

Given the contamination of live poultry markets and backyard poultry, AI H5N6 variants and genotypes will continuously emerge; therefore, enhancing surveillance is crucial for pandemic preparedness.

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来源期刊

International Journal of Infectious Diseases 医学-传染病学

CiteScore

18.90

自引率

2.40%

发文量

1020

审稿时长

30 days

期刊介绍： International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.