抗 MDA5 阳性：描述临床明显的 MDA5 疾病的频率和范围。

IF 1.8 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Internal Medicine Journal Pub Date : 2024-11-11 DOI:10.1111/imj.16563

Janelle See, Jessica L. Fairley, Ai L. Yeo, Samar Ojaimi, Eric F. Morand

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引用次数: 0

摘要

为了评估一家三级风湿病服务机构在黑色素瘤分化关联蛋白-5（MDA5）疾病和检测方面的经验，我们对自身抗体检测结果呈阳性的患者进行了临床疾病复查。在 2% 的肌炎特异性抗体检测中发现了抗 MDA5 阳性。其中 29% 的患者没有与抗 MDA5 疾病一致的特征。然而，一旦出现，MDA5 病症严重，死亡率很高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Anti-MDA5 positivity: describing the frequency and spectrum of clinically evident MDA5 disease

To evaluate experience in a tertiary rheumatology service with melanoma differentiation-association-protein-5 (MDA5) disease and testing, patients with positive autoantibody results were reviewed for the presence of clinical disease. Anti-MDA5 positivity was detected in 2% of myositis-specific antibody tests. Of these, 29% did not have features consistent with anti-MDA5 disease. However, when present, MDA5 disease is severe with a high mortality.

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来源期刊

Internal Medicine Journal 医学-医学：内科

CiteScore

3.50

自引率

4.80%

发文量

600

审稿时长

3-6 weeks

期刊介绍： The Internal Medicine Journal is the official journal of the Adult Medicine Division of The Royal Australasian College of Physicians (RACP). Its purpose is to publish high-quality internationally competitive peer-reviewed original medical research, both laboratory and clinical, relating to the study and research of human disease. Papers will be considered from all areas of medical practice and science. The Journal also has a major role in continuing medical education and publishes review articles relevant to physician education.