衰老和虚弱与慢性鼻炎患者的炎症内型转变有关。

IF 7.2 2区医学 Q1 OTORHINOLARYNGOLOGY

International Forum of Allergy & Rhinology Pub Date : 2024-11-13 DOI:10.1002/alr.23484

Mason R Krysinski, Christina Dorismond, Yash Trivedi, Rory Lubner, Andrea A Lopez, Kolin Rubel, Rakesh K Chandra, Naweed I Chowdhury, Justin H Turner

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引用次数: 0

摘要

要点：虚弱和衰老与慢性鼻窦炎（CRS）向非 2 型炎症转变有关。与衰弱相关的鼻窦炎症介质的变化可能与生物衰老有关。了解衰老和虚弱在 CRS 中的作用可能会对治疗产生重要影响。

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Aging and frailty are associated with inflammatory endotypic shifts in patients with chronic rhinosinusitis.

Key points: Frailty and aging are associated with a shift toward non-type 2 inflammation in chronic rhinosinusitis (CRS). Frailty-related shifts in sinonasal inflammatory mediators may be linked to biological senescence. Understanding the role of aging and frailty in CRS may have important treatment implications.

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来源期刊

International Forum of Allergy & Rhinology OTORHINOLARYNGOLOGY-

CiteScore

11.70

自引率

10.90%

发文量

185

审稿时长

6-12 weeks

期刊介绍： International Forum of Allergy & Rhinologyis a peer-reviewed scientific journal, and the Official Journal of the American Rhinologic Society and the American Academy of Otolaryngic Allergy. International Forum of Allergy Rhinology provides a forum for clinical researchers, basic scientists, clinicians, and others to publish original research and explore controversies in the medical and surgical treatment of patients with otolaryngic allergy, rhinologic, and skull base conditions. The application of current research to the management of otolaryngic allergy, rhinologic, and skull base diseases and the need for further investigation will be highlighted.