间充质干细胞源性细胞外囊泡药物递送的研究热点和趋势:2013-2023年文献计量和可视化分析。

IF 4.6 2区 生物学 Q2 CELL BIOLOGY
Frontiers in Cell and Developmental Biology Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI:10.3389/fcell.2024.1412363
Tianyuan Zhao, Yuhao Mu, Haobin Deng, Kaini Liang, Fanfan Zhou, Qiyuan Lin, Fuyang Cao, Feifei Zhou, Zhen Yang
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引用次数: 0

摘要

导言:我们的研究旨在全面概述间充质干细胞衍生细胞外囊泡(MSC-EVs)在给药研究中的应用,重点关注2013年至2023年期间的研究。鉴于全球对这一领域的兴趣与日俱增,我们利用文献计量学工具探讨了发表趋势、主要贡献者和专题研究集群:数据收集自科学网(WoS)数据库,并使用 VOSviewer 进行了深入的文献计量分析。该分析涵盖了书目耦合、共引、合著和共现趋势,提供了对全球研究活动的结构性洞察。我们还利用 Citespace 进一步分析了这一领域的主题集群:我们的分析显示,在过去十年中,共有 1,045 篇论文涉及间充质干细胞-EVs 在药物递送中的应用,显示出研究成果的稳步增长。中国在论文数量、H 指数、多产作者和研究经费方面均居首位,而美国则在总引用次数、平均引用次数和 H 指数表现方面名列前茅。按出版量计算,《制药学》成为领先期刊,而《控释期刊》的总链接强度最高。推动研究的顶尖机构包括上海交通大学、浙江大学和哈佛大学。VOSviewer 分析确定了四大研究集群:组织工程、癌症、神经疾病和靶向给药。Citespace 分析将其进一步细化为十个主题领域,包括分化、组织再生和耐药性:这项文献计量学评估全面展示了间充质干细胞-EVs在药物递送方面的研究状况,强调了中国和美国的重大贡献。我们的研究结果强调了间充质干细胞-EV研究在全球范围内日益增长的重要性,并突出了可能指导未来研究方向的新兴主题。本研究的见解为确定间充质干细胞-EV药物递送的新兴前沿领域提供了一个基础框架。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Research hotspots and trends of mesenchymal stem cell-derived extracellular vesicles for drug delivery: a bibliometric and visualization analysis from 2013 to 2023.

Introduction: Our study aims to provide a comprehensive overview of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) in drug delivery research, focusing on the period between 2013 and 2023. Given the increasing global interest in this field, we utilized bibliometric tools to explore publication trends, key contributors, and thematic research clusters.

Methods: Data was collected from the Web of Science (WoS) database, and an in-depth bibliometric analysis was conducted using VOSviewer. The analysis encompassed bibliographic coupling, co-citation, co-authorship, and co-occurrence trends, offering a structured insight into global research activity. We also employed Citespace to further analyze thematic clusters in this domain.

Results: Our analysis revealed a total of 1,045 publications related to MSC-EVs in drug delivery over the past decade, showing a steady increase in research output. China led in publication count, H-index, prolific authors, and research funding, while the United States ranked highest in total citations, average citation counts, and H-index performance. Pharmaceutics emerged as the leading journal by publication volume, with the Journal of Controlled Release having the strongest total link strength. Top institutions driving research included Shanghai Jiao Tong University, Zhejiang University, and Harvard University. VOSviewer analysis identified four major research clusters: tissue engineering, cancer, neurological diseases, and targeted delivery. Citespace analysis refined this further into ten thematic areas, including differentiation, tissue regeneration, and drug resistance.

Discussion: This bibliometric assessment provides a holistic visualization of the research landscape for MSC-EVs in drug delivery, underlining the significant contributions of China and the United States. Our findings underscore the increasing global importance of MSC-EV research and highlight emerging themes that will likely guide future research directions. The insights from this study offer a foundational framework for identifying nascent frontiers in MSC-EV-based drug delivery.

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来源期刊
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
9.70
自引率
3.60%
发文量
2531
审稿时长
12 weeks
期刊介绍: Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board. The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology. With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.
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