美罗培南-瓦巴坦作为鞘内保留疗法治疗耐碳青霉烯类的肺炎克氏菌分流相关脑室炎：两例病例报告和文献综述。

IF 3.7 3区医学 Q2 INFECTIOUS DISEASES

European Journal of Clinical Microbiology & Infectious Diseases Pub Date : 2024-11-12 DOI:10.1007/s10096-024-04986-6

Gabriele Giuliano, Margherita Sambo, Paola Castellani, Sara Benedetti, Francesca Tarantino, Mario Tumbarello

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引用次数: 0

摘要

最近，神经外科手术后脑室炎和脑膜炎的多重耐药革兰氏阴性菌病例有所增加。由于抗生素的供应有限，而且需要选择具有最佳药效学和药代动力学特征的抗生素，治疗这些感染已成为一项挑战。关于使用美罗培南-伐巴坦治疗中枢神经系统耐碳青霉烯类肠杆菌感染的证据有限。我们报告了两例新的耐碳青霉烯类肺炎克氏菌引起的顺行性脑室炎病例，在静脉滴注美罗培南-伐硼内酰胺联合疗法后，微生物学变化良好。

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Meropenem-vaborbactam as intrathecal-sparing therapy for the treatment of carbapenem-resistant K. pneumoniae shunt-related ventriculitis: two case reports and review of the literature.

Recently, an increase in cases of multidrug-resistant Gram-negative bacteria post-neurosurgical ventriculitis and meningitis is reported. Treating these infections has become challenging due to the limited availability of antibiotics and the need to select those with optimal pharmacodynamic and pharmacokinetic profiles. There is limited evidence regarding the use of meropenem-vaborbactam in treating carbapenem-resistant Enterobacterales infections of the central nervous system. We report two new cases of shunt-related ventriculitis due to carbapenem-resistant K.pneumoniae with a favorable microbiological evolution after IV only combination therapy with meropenem-vaborbactam.

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来源期刊

European Journal of Clinical Microbiology & Infectious Diseases 医学-传染病学

CiteScore

10.40

自引率

2.20%

发文量

138

审稿时长

1 months

期刊介绍： EJCMID is an interdisciplinary journal devoted to the publication of communications on infectious diseases of bacterial, viral and parasitic origin.