{"title":"HECTD4 基因变异、肥胖与饮用咖啡之间的关系。","authors":"Min-Jeong Kim, Hyun-Seok Jin, Yong-Bin Eom","doi":"10.1038/s41430-024-01541-6","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>In genome-wide association studies, the HECT domain E3 ubiquitin-protein ligase 4 (HECTD4) gene was suggested to be associated with obesity-related traits and coffee consumption. However, the association of genetic variants between coffee consumption and obesity has not been tested in Koreans. Therefore, we investigated whether HECTD4 gene variants act as effect modifiers on the relationship between obesity and coffee.</p><p><strong>Methods: </strong>This study analyzed the correlation between coffee consumption and obesity among 58,698 individuals representing the Health Examinees. Participants were categorized into obese (BMI ≥ 25.0 kg/m<sup>2</sup>) and nonobese (18.5 ≤ BMI < 23.0 kg/m<sup>2</sup>). Food consumption was assessed by a food frequency questionnaire.</p><p><strong>Results: </strong>We identified four HECTD4 gene variants associated with obesity-related traits and coffee consumption based on Bonferroni-corrected significance level (p < 0.00014). Furthermore, multivariate logistic regression analysis confirmed that the impact of coffee consumption on obesity differed based on the HECTD4 rs2074356 genotypes. A positive correlation between obesity and coffee consumption was observed, with a more pronounced effect in individuals with the G allele (OR = 1.61 for 1 to <2 cups/day, p = 1.89 × 10<sup>-37</sup>; OR = 1.82 for ≥2 cups/day, p = 1.73 × 10<sup>-42</sup>) than in those with the A allele (OR = 1.47 for 1 to <2 cups/day, p = 7.41 × 10<sup>-17</sup>; OR = 1.45 for ≥2 cups/day, p = 7.24 × 10<sup>-11</sup>).</p><p><strong>Conclusion: </strong>Our findings suggest that the influence of coffee consumption on obesity may vary in Koreans depending on the HECTD4 gene variant.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Relationship between HECTD4 gene variants, obesity, and coffee consumption.\",\"authors\":\"Min-Jeong Kim, Hyun-Seok Jin, Yong-Bin Eom\",\"doi\":\"10.1038/s41430-024-01541-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>In genome-wide association studies, the HECT domain E3 ubiquitin-protein ligase 4 (HECTD4) gene was suggested to be associated with obesity-related traits and coffee consumption. However, the association of genetic variants between coffee consumption and obesity has not been tested in Koreans. Therefore, we investigated whether HECTD4 gene variants act as effect modifiers on the relationship between obesity and coffee.</p><p><strong>Methods: </strong>This study analyzed the correlation between coffee consumption and obesity among 58,698 individuals representing the Health Examinees. Participants were categorized into obese (BMI ≥ 25.0 kg/m<sup>2</sup>) and nonobese (18.5 ≤ BMI < 23.0 kg/m<sup>2</sup>). Food consumption was assessed by a food frequency questionnaire.</p><p><strong>Results: </strong>We identified four HECTD4 gene variants associated with obesity-related traits and coffee consumption based on Bonferroni-corrected significance level (p < 0.00014). Furthermore, multivariate logistic regression analysis confirmed that the impact of coffee consumption on obesity differed based on the HECTD4 rs2074356 genotypes. A positive correlation between obesity and coffee consumption was observed, with a more pronounced effect in individuals with the G allele (OR = 1.61 for 1 to <2 cups/day, p = 1.89 × 10<sup>-37</sup>; OR = 1.82 for ≥2 cups/day, p = 1.73 × 10<sup>-42</sup>) than in those with the A allele (OR = 1.47 for 1 to <2 cups/day, p = 7.41 × 10<sup>-17</sup>; OR = 1.45 for ≥2 cups/day, p = 7.24 × 10<sup>-11</sup>).</p><p><strong>Conclusion: </strong>Our findings suggest that the influence of coffee consumption on obesity may vary in Koreans depending on the HECTD4 gene variant.</p>\",\"PeriodicalId\":11927,\"journal\":{\"name\":\"European Journal of Clinical Nutrition\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2024-11-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Clinical Nutrition\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41430-024-01541-6\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Clinical Nutrition","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41430-024-01541-6","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Relationship between HECTD4 gene variants, obesity, and coffee consumption.
Background: In genome-wide association studies, the HECT domain E3 ubiquitin-protein ligase 4 (HECTD4) gene was suggested to be associated with obesity-related traits and coffee consumption. However, the association of genetic variants between coffee consumption and obesity has not been tested in Koreans. Therefore, we investigated whether HECTD4 gene variants act as effect modifiers on the relationship between obesity and coffee.
Methods: This study analyzed the correlation between coffee consumption and obesity among 58,698 individuals representing the Health Examinees. Participants were categorized into obese (BMI ≥ 25.0 kg/m2) and nonobese (18.5 ≤ BMI < 23.0 kg/m2). Food consumption was assessed by a food frequency questionnaire.
Results: We identified four HECTD4 gene variants associated with obesity-related traits and coffee consumption based on Bonferroni-corrected significance level (p < 0.00014). Furthermore, multivariate logistic regression analysis confirmed that the impact of coffee consumption on obesity differed based on the HECTD4 rs2074356 genotypes. A positive correlation between obesity and coffee consumption was observed, with a more pronounced effect in individuals with the G allele (OR = 1.61 for 1 to <2 cups/day, p = 1.89 × 10-37; OR = 1.82 for ≥2 cups/day, p = 1.73 × 10-42) than in those with the A allele (OR = 1.47 for 1 to <2 cups/day, p = 7.41 × 10-17; OR = 1.45 for ≥2 cups/day, p = 7.24 × 10-11).
Conclusion: Our findings suggest that the influence of coffee consumption on obesity may vary in Koreans depending on the HECTD4 gene variant.
期刊介绍：
The European Journal of Clinical Nutrition (EJCN) is an international, peer-reviewed journal covering all aspects of human and clinical nutrition. The journal welcomes original research, reviews, case reports and brief communications based on clinical, metabolic and epidemiological studies that describe methodologies, mechanisms, associations and benefits of nutritional interventions for clinical disease and health promotion.
Topics of interest include but are not limited to:
Nutrition and Health (including climate and ecological aspects)
Metabolism & Metabolomics
Genomics and personalized strategies in nutrition
Nutrition during the early life cycle
Health issues and nutrition in the elderly
Phenotyping in clinical nutrition
Nutrition in acute and chronic diseases
The double burden of ''malnutrition'': Under-nutrition and Obesity
Prevention of Non Communicable Diseases (NCD)
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