异维A酸会增加寻常型痤疮患者胰岛素抵抗的非胰岛素替代指标。

IF 1.6 4区 医学 Q3 OPHTHALMOLOGY
Kadir Kaya, Özlem Gevher
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引用次数: 0

摘要

背景:血脂指数,尤其是甘油三酯-葡萄糖指数(TyG指数)和甘油三酯/高密度脂蛋白胆固醇(TG/HDL-C)比值,是一种简单、可靠、非胰岛素替代性胰岛素抵抗标志物,近来日益受到重视。本研究旨在评估异维A酸治疗对寻常型痤疮(AV)患者胰岛素抵抗替代指标,尤其是TyG指数的影响:这项回顾性研究回顾了 2023 年 9 月至 2024 年 3 月期间在皮肤病与性病科接受异维A酸治疗的 200 名寻常型痤疮患者的病历。研究记录了血清空腹血糖、空腹血脂谱[甘油三酯(TG)、总胆固醇(TC)、极低密度脂蛋白胆固醇(VLDL-C)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]和其他生化参数。甘油三酯-葡萄糖(TyG)指数值的计算公式为 Ln [空腹甘油三酯(毫克/分升)×空腹血浆葡萄糖(毫克/分升)/2]。将治疗前的数值与治疗 5 个月后的数值进行比较:结果:TyG 指数、TG/HDL、TC/HDL 和 LDL/HDL 比率均有显著的统计学增长(p p p p 结论:TyG 指数和 TG/HDL 比率均有显著的统计学增长:本研究结果表明,异维A酸治疗可能会通过增加胰岛素抵抗的替代生物标志物来增加 AV 患者的胰岛素抵抗。我们还建议在治疗随访中使用 TyG 指数和其他血脂指数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Isotretinoin increases non-insulin-based surrogate markers of insulin resistance in acne vulgaris patients.

Background: Lipid indices, particularly the triglyceride-glucose index (TyG index) and the triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio, are simple, reliable, non-insulin-based surrogate markers of insulin resistance that have recently gained prominence. The aim of this study was to evaluate the effect of isotretinoin treatment on surrogate markers of insulin resistance, in particular the TyG index, in patients with acne vulgaris (AV).

Materials and methods: This retrospective study reviewed the records of 200 patients who received isotretinoin treatment for acne vulgaris at the Department of Dermatology and Venereology between September 2023 and March 2024. Serum fasting glucose, fasting lipid profile [triglyceride (TG), total cholesterol (TC), very low-density lipoprotein cholesterol (VLDL-C), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C)] and other biochemical parameters were recorded. Triglyceride-glucose (TyG) index value was calculated with the formula Ln [fasting triglyceride (mg/dL) × fasting plasma glucose (mg/dL)/2]. Pre-treatment values were compared with values after 5 months of treatment.

Results: TyG index and TG/HDL, TC/HDL, and LDL/HDL ratios all increased statistically significantly (p < 0.001). In addition, a positive correlation was found between pre- and post-treatment TyG index values and pre- and post-treatment TC/HDL, LDL/HDL and TG/HDL ratio values (p < 0.001). Among lipid measurements, triglycerides, total cholesterol, VLDL-C, LDL-C increased statistically significantly (p < 0.001), while HDL-C decreased statistically significantly (p < 0.05).

Conclusion: The results of this study suggest that isotretinoin treatment may increase insulin resistance in AV patients by increasing surrogate biomarkers of insulin resistance. We also suggest that the TyG index and other lipid indices can be used in treatment follow-up.

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来源期刊
CiteScore
3.30
自引率
6.20%
发文量
40
审稿时长
1 months
期刊介绍: Cutaneous and Ocular Toxicology is an international, peer-reviewed journal that covers all types of harm to cutaneous and ocular systems. Areas of particular interest include pharmaceutical and medical products; consumer, personal care, and household products; and issues in environmental and occupational exposures. In addition to original research papers, reviews and short communications are invited, as well as concise, relevant, and critical reviews of topics of contemporary significance.
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