Li-Ping Fei, He-He Zhao, Zhong-Nian Yang, Shi Wang, Yan Guo, Hui Gong, Jie Yang, Hou-Lin Tang, Fang-Fang Chen, Mao-He Yu, Fan Lv
{"title":"中国天津 18-24 岁男男性行为者的 HIV 感染率和娱乐性毒品使用情况：一项回顾性队列研究。","authors":"Li-Ping Fei, He-He Zhao, Zhong-Nian Yang, Shi Wang, Yan Guo, Hui Gong, Jie Yang, Hou-Lin Tang, Fang-Fang Chen, Mao-He Yu, Fan Lv","doi":"10.1186/s12879-024-10184-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Recreational drug use has been identified as a significant risk factor for the transmission of human immunodeficiency virus (HIV). This behavior is particularly prevalent among young men who have sex with men (YMSM). However, limited research has been conducted to investigate the correlation between recreational drug use and HIV incidence within this population.</p><p><strong>Objective: </strong>To examine HIV incidence and explore the association between recreational drug use and HIV incidence among YMSM.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted by a local non-governmental organization (NGO) among MSM aged 18-24 years from October 2017 to December 2023 in Tianjin, China. Participants were included if they had at least two HIV test records during this period. HIV incidence density and its 95% confidence interval (CI) were calculated using person-years (PYs) with a Poisson distribution. Risk factors for HIV incidence were identified using univariable and multivariable Cox proportional hazards regression models.</p><p><strong>Results: </strong>A total of 56 HIV seroconversions were reported with 2901.9 PYs, resulting in an overall incidence density of 1.9/100 PYs (95% CI: 1.4-2.4). Among YMSM who do not use recreational drugs (YMSM-URD), the incidence density was 1.1/100 PYs (95% CI: 0.5-1.6), while it was 2.8/100 PYs (95% CI: 1.9-3.7) among those who do use recreational drugs (YMSM-RD). Adjusted for confounders, factors associated with HIV infection included recreational drug use (adjusted hazard ratio = 2.6, 95% CI = 1.4-4.7) and unprotected anal intercourse in the past six months (adjusted hazard ratio = 2.3, 95% CI = 1.2-4.4).</p><p><strong>Conclusions: </strong>Recreational drug use and unprotected anal intercourse significantly increase the risk of HIV infection. To effectively mitigate the spread of HIV, interventions should focus on these risk factors by employing HIV counseling and testing clinics, collaborating with NGOs focused on MSM, and establishing peer education programs aimed at YMSM.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"24 1","pages":"1295"},"PeriodicalIF":3.4000,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11562522/pdf/","citationCount":"0","resultStr":"{\"title\":\"HIV incidence and recreational drug use among men who have sex with men aged 18-24 years in Tianjin, China: a retrospective cohort study.\",\"authors\":\"Li-Ping Fei, He-He Zhao, Zhong-Nian Yang, Shi Wang, Yan Guo, Hui Gong, Jie Yang, Hou-Lin Tang, Fang-Fang Chen, Mao-He Yu, Fan Lv\",\"doi\":\"10.1186/s12879-024-10184-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Recreational drug use has been identified as a significant risk factor for the transmission of human immunodeficiency virus (HIV). This behavior is particularly prevalent among young men who have sex with men (YMSM). However, limited research has been conducted to investigate the correlation between recreational drug use and HIV incidence within this population.</p><p><strong>Objective: </strong>To examine HIV incidence and explore the association between recreational drug use and HIV incidence among YMSM.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted by a local non-governmental organization (NGO) among MSM aged 18-24 years from October 2017 to December 2023 in Tianjin, China. Participants were included if they had at least two HIV test records during this period. HIV incidence density and its 95% confidence interval (CI) were calculated using person-years (PYs) with a Poisson distribution. Risk factors for HIV incidence were identified using univariable and multivariable Cox proportional hazards regression models.</p><p><strong>Results: </strong>A total of 56 HIV seroconversions were reported with 2901.9 PYs, resulting in an overall incidence density of 1.9/100 PYs (95% CI: 1.4-2.4). Among YMSM who do not use recreational drugs (YMSM-URD), the incidence density was 1.1/100 PYs (95% CI: 0.5-1.6), while it was 2.8/100 PYs (95% CI: 1.9-3.7) among those who do use recreational drugs (YMSM-RD). Adjusted for confounders, factors associated with HIV infection included recreational drug use (adjusted hazard ratio = 2.6, 95% CI = 1.4-4.7) and unprotected anal intercourse in the past six months (adjusted hazard ratio = 2.3, 95% CI = 1.2-4.4).</p><p><strong>Conclusions: </strong>Recreational drug use and unprotected anal intercourse significantly increase the risk of HIV infection. To effectively mitigate the spread of HIV, interventions should focus on these risk factors by employing HIV counseling and testing clinics, collaborating with NGOs focused on MSM, and establishing peer education programs aimed at YMSM.</p>\",\"PeriodicalId\":8981,\"journal\":{\"name\":\"BMC Infectious Diseases\",\"volume\":\"24 1\",\"pages\":\"1295\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2024-11-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11562522/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMC Infectious Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12879-024-10184-8\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Infectious Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12879-024-10184-8","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
摘要
背景：娱乐性吸毒已被确定为传播人体免疫缺陷病毒（HIV）的一个重要风险因素。这种行为在男男性行为者（YMSM）中尤为普遍。然而，对这一人群中娱乐性吸毒与 HIV 感染率之间相关性的研究却很有限：研究青年男男性行为者中的 HIV 感染率，并探讨娱乐性吸毒与 HIV 感染率之间的关联：方法：2017 年 10 月至 2023 年 12 月，一家当地非政府组织（NGO）在中国天津对 18-24 岁的 MSM 进行了一项回顾性队列研究。在此期间至少有两次 HIV 检测记录的参与者均被纳入研究范围。HIV发病密度及其95%置信区间（CI）采用泊松分布的人年（PY）进行计算。使用单变量和多变量考克斯比例危险回归模型确定了艾滋病发病率的风险因素：在 2901.9 PYs 中，共报告了 56 例 HIV 血清转换，总发病密度为 1.9/100 PYs（95% CI：1.4-2.4）。在不使用娱乐性毒品的 YMSM（YMSM-URD）中，发病密度为 1.1/100 PYs（95% CI：0.5-1.6），而在使用娱乐性毒品的 YMSM（YMSM-RD）中，发病密度为 2.8/100 PYs（95% CI：1.9-3.7）。经混杂因素调整后，与艾滋病毒感染相关的因素包括使用娱乐性毒品（调整后的危险比 = 2.6，95% CI = 1.4-4.7）和过去六个月内无保护肛交（调整后的危险比 = 2.3，95% CI = 1.2-4.4）：结论：娱乐性吸毒和无保护肛交会大大增加感染艾滋病毒的风险。为了有效减少艾滋病病毒的传播，干预措施应针对这些风险因素，开设艾滋病病毒咨询和检测诊所，与关注男男性行为者的非政府组织合作，并建立针对男男性行为者的同伴教育计划。
HIV incidence and recreational drug use among men who have sex with men aged 18-24 years in Tianjin, China: a retrospective cohort study.
Background: Recreational drug use has been identified as a significant risk factor for the transmission of human immunodeficiency virus (HIV). This behavior is particularly prevalent among young men who have sex with men (YMSM). However, limited research has been conducted to investigate the correlation between recreational drug use and HIV incidence within this population.
Objective: To examine HIV incidence and explore the association between recreational drug use and HIV incidence among YMSM.
Methods: A retrospective cohort study was conducted by a local non-governmental organization (NGO) among MSM aged 18-24 years from October 2017 to December 2023 in Tianjin, China. Participants were included if they had at least two HIV test records during this period. HIV incidence density and its 95% confidence interval (CI) were calculated using person-years (PYs) with a Poisson distribution. Risk factors for HIV incidence were identified using univariable and multivariable Cox proportional hazards regression models.
Results: A total of 56 HIV seroconversions were reported with 2901.9 PYs, resulting in an overall incidence density of 1.9/100 PYs (95% CI: 1.4-2.4). Among YMSM who do not use recreational drugs (YMSM-URD), the incidence density was 1.1/100 PYs (95% CI: 0.5-1.6), while it was 2.8/100 PYs (95% CI: 1.9-3.7) among those who do use recreational drugs (YMSM-RD). Adjusted for confounders, factors associated with HIV infection included recreational drug use (adjusted hazard ratio = 2.6, 95% CI = 1.4-4.7) and unprotected anal intercourse in the past six months (adjusted hazard ratio = 2.3, 95% CI = 1.2-4.4).
Conclusions: Recreational drug use and unprotected anal intercourse significantly increase the risk of HIV infection. To effectively mitigate the spread of HIV, interventions should focus on these risk factors by employing HIV counseling and testing clinics, collaborating with NGOs focused on MSM, and establishing peer education programs aimed at YMSM.
期刊介绍：
BMC Infectious Diseases is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of infectious and sexually transmitted diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology.
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