{"title":"乍得各省医疗机构门诊患者的 SARS-CoV-2 血清流行率及相关因素。","authors":"Koutaya Dezoumbe, Oumaima Djarma, Andrillene Laure Deutou Wondeu, Fatima Abdelrazak Zakaria, Sabrina Atturo, Nathan Naïbeï, Franck J D Mennechet, Denise Campagna, Abdoulaye Boukar, Choroma Ahmat Moussa, Issa Mahamat, Nontegyol Armand, Mahamat Idriss Hamad, Netalar Honorine, Kayanlengar Frederic, Adam Adami Moustapha, Yanda Mberkissam Daniel, Adam Moussa Alim, Mahamat Grene, Noubaramadji Yamti Suitombaye, Amine Akouya, Ouchemi Choua, Hota Mathieu, Djallaye Djimtoïbaye, Vittorio Colizzi, Giulia Cappelli, Takoudjou Dzomo Guy Rodrigue, Mahamat Fayiz Abakar, Ali Mahamat Moussa","doi":"10.1186/s12879-024-10099-4","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Chad with 7,698 confirmed cases of infection and 194 deaths since the beginning of the COVID-19 pandemic, is one of the African countries with the lowest reported case numbers. However, this figure likely underestimates the true spread of the virus due to the low rate of diagnosis. The high rate of asymptomatic infections reflects the reality of SARS-CoV-2 transmission in Chad. In this study, we estimated the seroprevalence and identified factors associated with SARS-CoV-2 infection.</p><p><strong>Methods: </strong>A cross-sectional study was conducted between September 2022 and February 2023. A total of 1,290 plasma samples were collected from outpatient attendees at Health Facilities located in 11 provinces of Chad and tested by ELISA method, for the presence of IgG antibodies to SARS-CoV2 nucleocapsid (N) protein. KoboToolbox was used to gather data from the participants and data were analyzed using STATA 16.</p><p><strong>Results: </strong>The overall seroprevalence was 83.0% [95% CI = 81.6%-85.5%], with variations between provinces, ranging from 99.2% [95% CI = 94.0%-100%] in Moundou (Southern Chad) to 46.8% [95% CI = 36.0% -57.1%] in Biltine (Eastern Chad). Factors associated with the seroprevalence included military occupation (OR = 0.37 CI [0.80-1.77] p = 0.025) and age group between 55-64 years (OR = 0.33 CI [0.15-0.72] p = 0.005). While, other factors, such as gender and age were not significantly associated with seroprevalence.</p><p><strong>Conclusion: </strong>Our results indicated that, the seroprevalence of COVID-19 in Chad is among the highest in Sub-Saharan Africa. These estimates could guide the response and public health policy decisions, enhancing the management of future outbreaks involving respiratory pathogens.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"24 1","pages":"1271"},"PeriodicalIF":3.4000,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552332/pdf/","citationCount":"0","resultStr":"{\"title\":\"SARS-CoV-2 seroprevalence and associated factors among outpatient attendees at health facilities in different provinces in Chad.\",\"authors\":\"Koutaya Dezoumbe, Oumaima Djarma, Andrillene Laure Deutou Wondeu, Fatima Abdelrazak Zakaria, Sabrina Atturo, Nathan Naïbeï, Franck J D Mennechet, Denise Campagna, Abdoulaye Boukar, Choroma Ahmat Moussa, Issa Mahamat, Nontegyol Armand, Mahamat Idriss Hamad, Netalar Honorine, Kayanlengar Frederic, Adam Adami Moustapha, Yanda Mberkissam Daniel, Adam Moussa Alim, Mahamat Grene, Noubaramadji Yamti Suitombaye, Amine Akouya, Ouchemi Choua, Hota Mathieu, Djallaye Djimtoïbaye, Vittorio Colizzi, Giulia Cappelli, Takoudjou Dzomo Guy Rodrigue, Mahamat Fayiz Abakar, Ali Mahamat Moussa\",\"doi\":\"10.1186/s12879-024-10099-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Chad with 7,698 confirmed cases of infection and 194 deaths since the beginning of the COVID-19 pandemic, is one of the African countries with the lowest reported case numbers. However, this figure likely underestimates the true spread of the virus due to the low rate of diagnosis. The high rate of asymptomatic infections reflects the reality of SARS-CoV-2 transmission in Chad. In this study, we estimated the seroprevalence and identified factors associated with SARS-CoV-2 infection.</p><p><strong>Methods: </strong>A cross-sectional study was conducted between September 2022 and February 2023. A total of 1,290 plasma samples were collected from outpatient attendees at Health Facilities located in 11 provinces of Chad and tested by ELISA method, for the presence of IgG antibodies to SARS-CoV2 nucleocapsid (N) protein. KoboToolbox was used to gather data from the participants and data were analyzed using STATA 16.</p><p><strong>Results: </strong>The overall seroprevalence was 83.0% [95% CI = 81.6%-85.5%], with variations between provinces, ranging from 99.2% [95% CI = 94.0%-100%] in Moundou (Southern Chad) to 46.8% [95% CI = 36.0% -57.1%] in Biltine (Eastern Chad). Factors associated with the seroprevalence included military occupation (OR = 0.37 CI [0.80-1.77] p = 0.025) and age group between 55-64 years (OR = 0.33 CI [0.15-0.72] p = 0.005). While, other factors, such as gender and age were not significantly associated with seroprevalence.</p><p><strong>Conclusion: </strong>Our results indicated that, the seroprevalence of COVID-19 in Chad is among the highest in Sub-Saharan Africa. These estimates could guide the response and public health policy decisions, enhancing the management of future outbreaks involving respiratory pathogens.</p>\",\"PeriodicalId\":8981,\"journal\":{\"name\":\"BMC Infectious Diseases\",\"volume\":\"24 1\",\"pages\":\"1271\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2024-11-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552332/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMC Infectious Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12879-024-10099-4\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Infectious Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12879-024-10099-4","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
摘要
背景：自 COVID-19 大流行以来，乍得确诊感染病例 7698 例，死亡 194 例，是报告病例数最少的非洲国家之一。然而，由于诊断率低，这一数字很可能低估了病毒的真实传播情况。无症状感染率高反映了 SARS-CoV-2 在乍得传播的实际情况。在这项研究中，我们估算了血清流行率，并确定了与 SARS-CoV-2 感染相关的因素：方法：我们在 2022 年 9 月至 2023 年 2 月期间进行了一项横断面研究。我们从乍得 11 个省医疗机构的门诊病人中收集了 1,290 份血浆样本，采用 ELISA 方法检测 SARS-CoV2 核头壳（N）蛋白 IgG 抗体。使用 KoboToolbox 收集参与者的数据，并使用 STATA 16 对数据进行分析：总血清阳性率为 83.0% [95% CI = 81.6% -85.5%]，各省之间存在差异，蒙杜（乍得南部）为 99.2% [95% CI = 94.0% -100%]，比尔廷（乍得东部）为 46.8% [95% CI = 36.0% -57.1%]。与血清阳性率相关的因素包括军人职业（OR = 0.37 CI [0.80-1.77] p = 0.025）和 55-64 岁年龄组（OR = 0.33 CI [0.15-0.72] p = 0.005）。而性别和年龄等其他因素与血清阳性率无明显关系：我们的研究结果表明，乍得的 COVID-19 血清流行率在撒哈拉以南非洲地区是最高的。这些估计值可为应对措施和公共卫生政策决策提供指导，从而加强对未来涉及呼吸道病原体的疫情的管理。
SARS-CoV-2 seroprevalence and associated factors among outpatient attendees at health facilities in different provinces in Chad.
Background: Chad with 7,698 confirmed cases of infection and 194 deaths since the beginning of the COVID-19 pandemic, is one of the African countries with the lowest reported case numbers. However, this figure likely underestimates the true spread of the virus due to the low rate of diagnosis. The high rate of asymptomatic infections reflects the reality of SARS-CoV-2 transmission in Chad. In this study, we estimated the seroprevalence and identified factors associated with SARS-CoV-2 infection.
Methods: A cross-sectional study was conducted between September 2022 and February 2023. A total of 1,290 plasma samples were collected from outpatient attendees at Health Facilities located in 11 provinces of Chad and tested by ELISA method, for the presence of IgG antibodies to SARS-CoV2 nucleocapsid (N) protein. KoboToolbox was used to gather data from the participants and data were analyzed using STATA 16.
Results: The overall seroprevalence was 83.0% [95% CI = 81.6%-85.5%], with variations between provinces, ranging from 99.2% [95% CI = 94.0%-100%] in Moundou (Southern Chad) to 46.8% [95% CI = 36.0% -57.1%] in Biltine (Eastern Chad). Factors associated with the seroprevalence included military occupation (OR = 0.37 CI [0.80-1.77] p = 0.025) and age group between 55-64 years (OR = 0.33 CI [0.15-0.72] p = 0.005). While, other factors, such as gender and age were not significantly associated with seroprevalence.
Conclusion: Our results indicated that, the seroprevalence of COVID-19 in Chad is among the highest in Sub-Saharan Africa. These estimates could guide the response and public health policy decisions, enhancing the management of future outbreaks involving respiratory pathogens.
期刊介绍：
BMC Infectious Diseases is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of infectious and sexually transmitted diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
