定向亲核芳香取代反应。

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2024-11-05 DOI:10.1039/d4cc04912h

Yasuyuki Nitta , Yusei Nakashima , Michinori Sumimoto , Takashi Nishikata

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引用次数: 0

摘要

在这项研究中，我们发现了一种定向亲核芳香取代反应，即 "定向 SNAr (dSNAr)"，它是在吡啶存在下，正交碘代氮杂酰胺与胺的反应。该反应以正交特异性方式进行，不需要炔基质上的强夺电子基团。大多数反应都是在室温、有 Py 存在的情况下进行的，而且可以使用多种胺类亲核物。此外，还发现与多个卤素取代的苯甲酰胺的反应具有 100% 的正选择性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Directed nucleophilic aromatic substitution reaction†

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Directed nucleophilic aromatic substitution reaction†

In this study, we discovered a directed nucleophilic aromatic substitution reaction, “directed SNAr (dSNAr),” in the reaction of ortho-iodobezamides and amine in the presence of pyridine. The reaction proceeded ortho-specifically and did not require a strong electron-withdrawing group on the arene substrate. Most reactions proceeded at room temperature in the presence of Py, and a wide range of amine nucleophiles can be applied. Furthermore, the reactions with benzamide substituted with multiple halogens were found to be 100% ortho-selective.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.