形成肝转移瘤转移前和转移壁龛的免疫动态：从分子机制到治疗策略

IF 6.7 1区化学 Q1 CHEMISTRY, ANALYTICAL

Analytical Chemistry Pub Date : 2024-11-14 DOI:10.1186/s12943-024-02171-z

Chang Zhu, Jing-Yu Liao, Yi-Yang Liu, Ze-Yu Chen, Rui-Zhi Chang, Xiao-Ping Chen, Bi-Xiang Zhang, Jun-Nan Liang

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引用次数: 0

摘要

肝转移通常在各种恶性肿瘤的晚期阶段被发现，是一项重大的临床挑战。在肝转移瘤形成的整个过程中，免疫细胞发挥着举足轻重的作用，尤其是在肝脏内的转移前和转移龛中。免疫细胞与肿瘤细胞和肝脏中的其他成分建立广泛而复杂的相互作用，共同促进和维持肝转移灶的生长。尽管现有治疗方法对某些晚期肝转移瘤的疗效有限，但人们仍在不断探索和验证基于免疫的新型治疗方法。在系统阐明肝转移瘤免疫抑制特征的基础上，我们从多个维度探索了适用于肝转移瘤患者的新型免疫疗法的潜力。

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Immune dynamics shaping pre-metastatic and metastatic niches in liver metastases: from molecular mechanisms to therapeutic strategies

Liver metastases are commonly detected in the advanced stages of various malignant tumors, representing a significant clinical challenge. Throughout the process of liver metastases formation, immune cells play a pivotal role, particularly in the pre-metastatic and metastatic niches within the liver. Immune cells establish extensive and intricate interactions with tumor cells and other components in the liver, collectively promoting and sustaining the growth of liver metastases. Despite the limited efficacy of existing therapeutic modalities against some advanced liver metastases, novel immune-based treatment approaches are continuously being explored and validated. Building on the systematic elucidation of the immunosuppressive characteristics of liver metastases, we explored the potential of novel immunotherapies applicable to patients with liver metastases from multiple dimensions.

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来源期刊

Analytical Chemistry 化学-分析化学

CiteScore

12.10

自引率

12.20%

发文量

1949

审稿时长

1.4 months

期刊介绍： Analytical Chemistry, a peer-reviewed research journal, focuses on disseminating new and original knowledge across all branches of analytical chemistry. Fundamental articles may explore general principles of chemical measurement science and need not directly address existing or potential analytical methodology. They can be entirely theoretical or report experimental results. Contributions may cover various phases of analytical operations, including sampling, bioanalysis, electrochemistry, mass spectrometry, microscale and nanoscale systems, environmental analysis, separations, spectroscopy, chemical reactions and selectivity, instrumentation, imaging, surface analysis, and data processing. Papers discussing known analytical methods should present a significant, original application of the method, a notable improvement, or results on an important analyte.