光催化与铜催化的结合:不对称多组分自由基交叉偶联反应的新机遇

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Peng-Zi Wang, Bin Zhang, Wen-Jing Xiao, Jia-Rong Chen
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引用次数: 0

摘要

近年来,自由基介导的交叉偶联反应已成为在良性条件下实现丰富多样的分子拓扑结构的一种引人注目的策略。然而,自由基固有的高反应活性给控制反应途径和选择性带来了相当大的挑战,这往往导致底物范围有限和反应曲线受限。鉴于可见光光氧化催化反应能够以受控方式产生多种活性自由基和自由基离子,以及铜络合物对自由基物种的倾向性,我们设想手性铜催化剂和光活性催化剂之间的协同作用将为开发创新战略铺平道路。这种整合有望开启广泛的对映选择性多组分自由基交叉偶联反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Photocatalysis Meets Copper Catalysis: A New Opportunity for Asymmetric Multicomponent Radical Cross-Coupling Reactions

Photocatalysis Meets Copper Catalysis: A New Opportunity for Asymmetric Multicomponent Radical Cross-Coupling Reactions
In recent years, radical-mediated cross-coupling reactions have emerged as a compelling strategy for achieving a rich diversity in molecular topologies under benign conditions. However, the inherent high reactivity of radicals presents considerable challenges in controlling reaction pathways and selectivity, which often results in a limited range of substrates and a constrained reaction profile. Given the capacity of visible-light photoredox catalysis to generate a wide variety of reactive radicals and radical ions in a controlled manner and the propensity of copper complexes toward radical species, we envisaged that the synergy between chiral copper catalysts and photoactive catalysts would pave the way for developing innovative strategies. This integration is poised to unlock a broad spectrum of enantioselective multicomponent radical cross-coupling reactions.
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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