嵌合抗原受体-T 细胞疗法后 B 细胞急性淋巴细胞白血病复发的机制；未来可行的策略。

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Biology Reports Pub Date : 2024-11-08 DOI:10.1007/s11033-024-10061-2

Masoud Karimi-Googheri, Mazaher Gholipourmalekabadi, Zahra Madjd, Ziba Shabani, Zhila Rostami, Mohammad Kazemi Arababadi, Jafar Kiani

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引用次数: 0

摘要

研究表明，B-急性淋巴细胞淋巴瘤（B-ALL）的死亡率和发病率都很高。研究人员已开发出多种治疗方法来对抗这种疾病。最近，研究人员开发出了嵌合抗原受体（CARs）-T 细胞，这种细胞能独立于主要组织相容性复合物（MHCs）识别抗原，并在更高水平上激活，具有更强的持久性。然而，复发性B-ALL也有多例报道。这篇综述文章旨在收集有关B-ALL相关淋巴细胞从CAR-T细胞中逃逸的机制的最新信息，以及可信的解决项目。

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The mechanisms of B-cell acute lymphoblastic leukemia relapsing following chimeric antigen receptor-T cell therapy; the plausible future strategies.

Research has demonstrated the high mortality and morbidity associated with B-Acute lymphoblastic lymphoma (B-ALL). Researchers have developed several therapeutic approaches to combat the disorder. Recently, researchers developed chimeric antigen receptors (CARs)-T cells, which recognize antigens independently of major histocompatibility complexes (MHCs) and activate at a higher level with additional persistence. However, relapsing B-ALL has been reported in several cases. This review article was aimed to collecting recent information regarding the mechanisms used by B-ALL-related lymphocytes to escape from CAR-T cells and the plausible resolution projects.

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来源期刊

Molecular Biology Reports 生物-生化与分子生物学

CiteScore

5.00

自引率

0.00%

发文量

1048

审稿时长

5.6 months

期刊介绍： Molecular Biology Reports publishes original research papers and review articles that demonstrate novel molecular and cellular findings in both eukaryotes (animals, plants, algae, funghi) and prokaryotes (bacteria and archaea).The journal publishes results of both fundamental and translational research as well as new techniques that advance experimental progress in the field and presents original research papers, short communications and (mini-) reviews.