用于白癜风靶向治疗的微针技术综述：设计原理、应用前景。

IF 4.7 2区医学 Q1 CHEMISTRY, MEDICINAL

Drug Design, Development and Therapy Pub Date : 2024-11-03 eCollection Date: 2024-01-01 DOI:10.2147/DDDT.S449381

Yihui Yu, Wei Li, Qian Li, Wenyan Liu, Sanquan Zhang, Xibao Zhang, Jingyao Liang

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引用次数: 0

摘要

白癜风是一种以皮肤色素脱失斑为特征的慢性自身免疫性疾病。白癜风的治疗仍然具有挑战性，部分原因是缺乏高效的给药系统。微针（MNs）是一种理想的透皮给药系统，已成为治疗白癜风的有前途的给药平台。最近，水凝胶和空心微针等生物相容性更强的新型微针的出现，进一步提高了微针在白癜风治疗中的转化价值。然而，有关这些进展的最新综述仍然缺乏。本综述旨在总结基于MN的白癜风给药系统的最新研究，突出MN作为治疗平台在不久的将来治疗白癜风的转化潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Review of Microneedle Technology for Targeted Therapeutics in Vitiligo: Design Principles, Application Prospects.

Vitiligo is a chronic autoimmune disorder characterized by depigmented patches of the skin. The treatment of vitiligo remains challenging, partly owing to the lack of efficient drug delivery system. Microneedles (MNs), an ideal transdermal drug delivery system, have emerged as promising drug delivery platform for vitiligo. Recently, the emergence of novel MNs with increased biocompatibility, including hydrogel and hollow MNs, further enhance the translational value of MNs in the treatment of vitiligo. However, up-to-date review of these advancements remains lacking. This review aims to summarize the most recent studies of MN-based drug delivery systems for vitiligo, highlighting the translational potential of MNs as a therapeutic platform for the treatment of vitiligo in the near future.

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来源期刊

Drug Design, Development and Therapy CHEMISTRY, MEDICINAL-PHARMACOLOGY & PHARMACY

CiteScore

9.00

自引率

0.00%

发文量

382

审稿时长

>12 weeks

期刊介绍： Drug Design, Development and Therapy is an international, peer-reviewed, open access journal that spans the spectrum of drug design, discovery and development through to clinical applications. The journal is characterized by the rapid reporting of high-quality original research, reviews, expert opinions, commentary and clinical studies in all therapeutic areas. Specific topics covered by the journal include: Drug target identification and validation Phenotypic screening and target deconvolution Biochemical analyses of drug targets and their pathways New methods or relevant applications in molecular/drug design and computer-aided drug discovery* Design, synthesis, and biological evaluation of novel biologically active compounds (including diagnostics or chemical probes) Structural or molecular biological studies elucidating molecular recognition processes Fragment-based drug discovery Pharmaceutical/red biotechnology Isolation, structural characterization, (bio)synthesis, bioengineering and pharmacological evaluation of natural products** Distribution, pharmacokinetics and metabolic transformations of drugs or biologically active compounds in drug development Drug delivery and formulation (design and characterization of dosage forms, release mechanisms and in vivo testing) Preclinical development studies Translational animal models Mechanisms of action and signalling pathways Toxicology Gene therapy, cell therapy and immunotherapy Personalized medicine and pharmacogenomics Clinical drug evaluation Patient safety and sustained use of medicines.