MAIIA EPO 纯化凝胶试剂盒，7D3--用于筛选和确认程序的替代纯化试剂盒。

IF 2.6 3区医学 Q2 BIOCHEMICAL RESEARCH METHODS

Drug Testing and Analysis Pub Date : 2024-11-07 DOI:10.1002/dta.3821

D Schwenke, J Hempel, A M Keiler, S C Voss

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引用次数: 0

摘要

本研究评估了新型 MAIIA EPO 纯化试剂盒 7D3 在人体尿样中的性能，以确认其符合世界反兴奋剂机构技术文件 2024（TD2024EPO）的标准。对试剂盒的选择性、最低要求性能水平 (MRPL) 的可靠性、检测限 (LOD)、携带率和回收率进行了验证。共检测了 81 份尿样的选择性、29 份尿样的最低要求性能水平（MRPL）和最低检测限（LOD）的可靠性以及 16 份尿样的回收率。该试剂盒符合即将发布的世界反兴奋剂机构 TD2024EPO 的标准和要求，为从人体尿液中提纯ERA 进行兴奋剂分析提供了有效的解决方案。

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The MAIIA EPO Purification Gel Kit, 7D3-An Alternative Purification Kit for Screening and Confirmation Procedures.

In this study, the performance of the new MAIIA EPO purification kit 7D3 was evaluated for human urine samples to confirm compliance with the WADA criteria of the WADA technical document 2024 (TD2024EPO). The kit was validated for selectivity, reliability at minimum required performance levels (MRPLs), limit of detection (LOD), carryover and recovery. A total of 81 urine samples were tested for selectivity, 29 samples for reliability at MRPL, LOD and 16 samples for recovery. The kit fulfils the criteria and the requirements of the upcoming WADA TD2024EPO and presents a valid solution for the purification of ERAs from human urine for doping analyses.

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来源期刊

Drug Testing and Analysis BIOCHEMICAL RESEARCH METHODS-CHEMISTRY, ANALYTICAL

CiteScore

5.90

自引率

24.10%

发文量

191

审稿时长

2.3 months

期刊介绍： As the incidence of drugs escalates in 21st century living, their detection and analysis have become increasingly important. Sport, the workplace, crime investigation, homeland security, the pharmaceutical industry and the environment are just some of the high profile arenas in which analytical testing has provided an important investigative tool for uncovering the presence of extraneous substances. In addition to the usual publishing fare of primary research articles, case reports and letters, Drug Testing and Analysis offers a unique combination of; ‘How to’ material such as ‘Tutorials’ and ‘Reviews’, Speculative pieces (‘Commentaries’ and ‘Perspectives'', providing a broader scientific and social context to the aspects of analytical testing), ‘Annual banned substance reviews’ (delivering a critical evaluation of the methods used in the characterization of established and newly outlawed compounds). Rather than focus on the application of a single technique, Drug Testing and Analysis employs a unique multidisciplinary approach to the field of controversial compound determination. Papers discussing chromatography, mass spectrometry, immunological approaches, 1D/2D gel electrophoresis, to name just a few select methods, are welcomed where their application is related to any of the six key topics listed below.