单相光谱 CT 导出的细胞外体积分数用于区分肾上腺转移瘤和腺瘤的可行性。

IF 2.3 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Abdominal Radiology Pub Date : 2024-11-08 DOI:10.1007/s00261-024-04681-2

Mengya Sun, Shulin Ma, Guanglei Tang, Weiwei Deng, Yang Peng, Shuang Yu, Jian Guan

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Various parameters were compared among the three groups. Diagnostic performance was evaluated by quantifying the area under the receiver operating characteristic curve (AUC).Results: The ECV fraction in group C (33.81 ± 11.94%) was significantly higher than that in group A (20.86 ± 10.22%) and group B (11.44 ± 6.26%) (p < 0.001), while iodine density in group C (0.93 ± 0.41 mg/mL) was also higher than that in group A (0.61 ± 0.33 mg/mL) and group B (0.33 ± 0.19 mg/mL) (p < 0.001). ECV fraction showed significantly higher AUC (AUC = 0.790, 95%CI 0.691-0.869) for differentiating between group A and C than iodine density (AUC = 0.717, 95%CI 0.612-0.808; p = 0.002). 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引用次数: 0

摘要

目的：肾上腺转移瘤的细胞外基质可能不同于肾上腺腺瘤的细胞外基质，而肾上腺腺瘤的细胞外基质可通过细胞外基质体积（ECV）来表征。本研究旨在评估单相频谱CT得出的ECV分数区分肾上腺转移瘤和腺瘤的可行性：这项回顾性研究纳入了 163 例单侧结节患者，包括贫脂肾上腺腺瘤（52 例，A 组）、富脂肾上腺腺瘤（65 例，B 组）和肾上腺转移瘤（46 例，C 组）。所有患者都接受了肾上腺造影剂增强频谱 CT，延迟期为 10 分钟。对每个病灶的碘密度进行评估，并检查ECV分数。对三组患者的各种参数进行了比较。通过量化接收者操作特征曲线下面积（AUC）来评估诊断性能：结果：C 组的 ECV 分数（33.81 ± 11.94%）明显高于 A 组（20.86 ± 10.22%）和 B 组（11.44 ± 6.26%）（p 结论：C 组的 ECV 分数（33.81 ± 11.94%）明显高于 A 组（20.86 ± 10.22%）和 B 组（11.44 ± 6.26%）：基于单次 10 分钟延迟相频谱 CT，ECV 分数在鉴别肾上腺转移瘤和肾上腺腺瘤方面表现出较高的诊断性能，无论是对于贫脂腺瘤还是富脂腺瘤。ECV分值有助于识别单侧或双侧肾上腺肿块的转移瘤，以便更好地制定治疗计划，尤其是对有肾上腺外恶性肿瘤病史的患者。

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Feasibility of extracellular volume fraction derived from single-phase spectral CT for differentiating between adrenal metastases and adenomas.

Purpose: The extracellular matrix of adrenal metastases could be different from that of the adrenal adenomas, which may be characterized by the extracellular volume (ECV) fraction. This study aimed to assess the feasibility of ECV fraction derived from single-phase spectral CT for differentiating between adrenal metastases and adenomas.

Methods: This retrospective study included 163 patients with unilateral nodules, including lipid-poor adrenal adenoma (n = 52, group A), lipid-rich adrenal adenoma (n = 65, group B) and adrenal metastasis (n = 46, group C). All patients underwent contrast-enhanced spectral CT of the adrenal gland with a 10-minute delayed phase. The iodine density of each lesion was assessed and ECV fraction was examined. Various parameters were compared among the three groups. Diagnostic performance was evaluated by quantifying the area under the receiver operating characteristic curve (AUC).

Results: The ECV fraction in group C (33.81 ± 11.94%) was significantly higher than that in group A (20.86 ± 10.22%) and group B (11.44 ± 6.26%) (p < 0.001), while iodine density in group C (0.93 ± 0.41 mg/mL) was also higher than that in group A (0.61 ± 0.33 mg/mL) and group B (0.33 ± 0.19 mg/mL) (p < 0.001). ECV fraction showed significantly higher AUC (AUC = 0.790, 95%CI 0.691-0.869) for differentiating between group A and C than iodine density (AUC = 0.717, 95%CI 0.612-0.808; p = 0.002). Simultaneously, ECV fraction had significantly higher AUC (AUC = 0.945, 95%CI 0.858-0.986) for differentiating between group B and C than iodine density (AUC = 0.897, 95%CI 0.795-0.959, p = 0.03).

Conclusion: Based on single 10-minute delayed phase spectral CT, ECV fraction showed high diagnostic performance in differentiating between adrenal metastases and adrenal adenomas, both for lipid-poor or lipid-rich adenomas. The ECV fraction could help recognize metastases in unilateral or bilateral adrenal masses for better treatment planning, especially in patients with a history of extra-adrenal malignancy.

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来源期刊

Abdominal Radiology Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

5.20

自引率

8.30%

发文量

334

期刊介绍： Abdominal Radiology seeks to meet the professional needs of the abdominal radiologist by publishing clinically pertinent original, review and practice related articles on the gastrointestinal and genitourinary tracts and abdominal interventional and radiologic procedures. Case reports are generally not accepted unless they are the first report of a new disease or condition, or part of a special solicited section. Reasons to Publish Your Article in Abdominal Radiology: · Official journal of the Society of Abdominal Radiology (SAR) · Published in Cooperation with: European Society of Gastrointestinal and Abdominal Radiology (ESGAR) European Society of Urogenital Radiology (ESUR) Asian Society of Abdominal Radiology (ASAR) · Efficient handling and Expeditious review · Author feedback is provided in a mentoring style · Global readership · Readers can earn CME credits